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More IVF Tries Improve Odds of Having a Baby

Some couples have success after six cycles or more, researchers saySource: HealthDay Related MedlinePlus Pages: Assisted Reproductive Technology, Infertility
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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In this study, the RNAs in the gonads of 1.5-year-old Japanese flounders were sequenced using Illumina. The miRNA expression profiles in the mature gonads of males and females were characterized. A total of 277 mature miRNAs were screened in both gonads. Among them, 25 miRNAs were expressed differently in the ovary and testis. Afterward, miR-1388 was selected for its high expression level in the ovary. Gene ontology analysis revealed that the target genes of miR-1388 were highly involved in cell-cell adhesion. Nectin2l, the target of miR-1388, is a Ca-independent cell adhesion molecule that was demonstrated to be testis-bi...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Category: Genetics & Stem Cells Source Type: research
In this study, we investigated the mechanistic basis for improvement of semen parameters and reversal of testis damage by QLPs in a rat model of oligoasthenospermia induced by treatment with tripterygium glycosides (TGs) (40 mg/kg) once daily for 4 weeks. Rats were administered QLPs (1.62 g/kg or 3.24 g/kg) each day for 60 days, with untreated animals serving as controls. The concentration and motility of sperm extracted from rat epididymis were determined, whereas histopathological examination and immunohistochemical apoptosis analysis of rat testes was performed. Expression profiles of apoptosis-related genes were determ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSIONS: Contraceptive self-injection has the potential to increase contraceptive access and use for adolescents in Uganda, and should be considered as a delivery modality in the context of adolescent-friendly contraceptive services. PMID: 29771679 [PubMed - as supplied by publisher]
Source: International Perspectives on Sexual and Reproductive Health - Category: International Medicine & Public Health Tags: Int Perspect Sex Reprod Health Source Type: research
(BJOG. 2017;124:1198–1205) Assisted reproductive technology (ART) is used in many countries as infertility occurs in ∼9% of the world population. In some European countries it has been reported that at least 3% of children were conceived via ART. Severe postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and the association between PPH and pregnancies achieved by ART is unclear. The aim of this case-control study was to determine whether an association exists between ART and severe PPH as well as to determine whether any association was affected by other risk factors for severe PPH.
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Mechanisms, Equipment, Hazards Source Type: research
I often see lots of infertile patients who could get pregnant if they did IVF treatment. Unfortunately, they just cannot afford to do an IVF cycle for financial reasons, and they end up without a baby. It fair to say  that  this causes them a significant amount of  frustration and heartburn when you know that IVF can help you get pregnant; but you can ’t, because you just can’t afford the treatment.Can this be changed? But it ’s not just the patients who are affected; IVF specialists also go through a lot of anguish when this happens. It’s very difficult to come to terms with the...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Inflammatory cytokines IL-6, IL-10, IL-13, TNF-α and peritoneal fluid flora were associated with infertility in patients with endometriosis. Eur Rev Med Pharmacol Sci. 2018 May;22(9):2513-2518 Authors: Wang XM, Ma ZY, Song N Abstract OBJECTIVE: To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS: A total of 55 patients diagnosed with endometriosis and infertility in the Gynecology Cl...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 18 May 2018 Source:Middle East Fertility Society Journal Author(s): Vasudha Gupta, Gita Radhakrishnan, Vinod Arora, Alpana Singh Objective Evaluation of endometrial scratching on pregnancy rates after IUI and comparing levels and distribution of IL-6 (inflammatory molecule) and E-Cadherin (adhesion molecule) by immunohistochemistry. Study design Randomized case control study. Setting Tertiary care hospital of Delhi, India. Material and methods 240 women (120 in each group) with previous failed IUI cycles were enrolled. Study group patients were subjected to endometrial scratch by “...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
ConclusionsA single, comprehensive, NGS panel can simplify the ordering process for healthcare providers, reduce turnaround time, and lower the overall cost of testing for genetic assessment of infertility in females and males, while maintaining accuracy.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Male factor infertility is quite common as 30 –50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA f...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
Authors: Nappi L, Ottaviano M, Rescigno P, Fazli L, Gleave ME, Damiano V, De Placido S, Palmieri G Abstract Background: Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated. Materials and Methods: 25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected. The tissu...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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