Molecular tests for the detection of antimicrobial resistant Neisseria gonorrhoeae: when, where, and how to use?

Purpose of review: Molecular methods for the diagnosis of Neisseria gonorrhoeae are replacing bacterial culture in many settings. This review focuses on recent progress in the development of molecular tests to detect resistant N. gonorrhoeae both to enhance surveillance and to guide decisions about individual patient management. Recent findings: Assays to enhance surveillance have been developed to detect determinants of resistance for all antibiotics used as first-line gonorrhoea treatment, or to detect specific ‘superbug’ strains, but few have been applied in clinical practice. The most advanced strategy relevant to individual case management is to identify ciprofloxacin-sensitive strains so that unnecessary use of ceftriaxone can be avoided. Cross-reactivity with pharyngeal commensal Neisseria species reduces specificity and is a challenge for many assays. Summary: Progress with laboratory-based molecular tests to detect gonococcal resistance is being made but substantial challenges remain. No laboratory-based assay has been subjected to a field evaluation and no assay so far can be used as a point-of-care test. Given the threat of antimicrobial resistance, now is the time to exploit the molecular technologies used for diagnosis and to invest in the development of molecular gonococcal resistance tests that can be implemented for public health good.
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: SEXUALLY TRANSMITTED DISEASES: Edited by Karen E. Rogstad Source Type: research

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Surgical site infections (SSI) represent undesired and potentially fatal complications in the context of colorectal surgery. On the other hand, antimicrobial resistance (AMR) is known for increasing the risk of adverse outcomes in several clinical conditions. We aimed to evaluate the association between AMR diagnosis and postoperative outcomes in patients that underwent open colectomy and developed a SSI.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and Rectal Surgery Source Type: research
Conditions:   Antimicrobial Resistance;   Neonatal Sepsis Intervention:   Other: No intervention Sponsors:   Children's Hospital of Fudan University;   Chinese Neonatal Network Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Packaging Technology and Science - Category: Food Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Conclusions The relatively high IR and low CR of penile HPV-16 and HPV-18 among HIV-negative MSM correlates with their high prevalence and oncogenic potential. Incident HPV infections were associated with recent sexual risk behavior.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
Conclusions While public health efforts often focus on MSM, non-MSM with STIs is also a subgroup at high risk of incident HIV diagnosis. Non-MSM and MSM with any STI, particularly syphilis, should be prioritized for HIV testing and prevention interventions.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
Conclusions Patients with undetermined risk for HIV constituted a large proportion of clinic visits and had a large volume of sexual health needs but rarely received PrEP when indicated. To end the HIV epidemic in the United States, prevention efforts must include people who fall outside traditional risk categories.
Source: Sexually Transmitted Diseases - Category: Sexual Medicine Tags: Original Studies Source Type: research
Conclusion: Alarming increase in the resistance to commonly used antimicrobials for gonorrhoea in our study, especially of fluoroquinolones, is a clarion call for the urgent need for prudence in prescribing them. Observing the rampant resistance exhibited by N. gonorrhoeae, it is clear that the day is not far when it will acquire a superbug status and become intractable to treatment by the available antibiotics.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Conclusion This large study found an association between having the MeNZB vaccine and a reduced likelihood of being diagnosed with gonorrhoea. But it's difficult to form any firm conclusions because of the nature of the case and control groups. For example, given that both groups were sexually active, we don't know why the majority of people with gonorrhoea didn't also have a chlamydia infection, and how this may have affected the results. It could just be down to pure chance and have nothing to do with the vaccine. So before we celebrate the alleged "cure of gonorrhoea", there are many things to consider: T...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Source Type: news
Conclusion The increase in antimicrobial resistance towards drugs used to treat gonorrhoea is reaching a critical stage, especially given how common the infection is worldwide, with an estimated 78 million new cases in 2012. This study raises concerns around an important topic while also proposing strategies to help address the slow pace of research and development of new drugs. The prevention of gonorrhoea is equally, if not more, important. The most effective way to prevent gonorrhoea is to always use a condom during sex, including anal and oral sex. Read more advice about sexually transmitted infections and how to prev...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication QA articles Source Type: news
7 July 2017 – Data from 77 countries show that antibiotic resistance is making gonorrhoea – a common sexually-transmitted infection – more difficult, and sometimes impossible, to treat. Some countries – particularly high-income ones, where surveillance is best – are finding cases of the infection tha t are untreatable by all known antibiotics. These cases may just be the tip of the iceberg, as gonorrhoea is more common in lower-income countries.
Source: WHO news - Category: International Medicine & Public Health Tags: antimicrobial resistance [subject], Press release [doctype] Source Type: news
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