Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

Conclusions Our data indicate that IGF1 pro-forms can induce breast cancer cell proliferation via the IGF1R, independent from the mature IGF1 form. These results underline the importance of an accurate assessment of the presence of IGF1 pro-forms within the breast cancer microenvironment.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research