Aprepitant for antiemesis after laparoscopic gynaecological surgery: A randomised controlled trial

CONCLUSION: Aprepitant 80 mg orally with ondansetron is effective in suppressing early PONV up to 24 h postoperatively and delays the time to first PONV in patients with fentanyl-based intravenous PCA after gynaecological laparoscopy. However, the combination prophylaxis with aprepitant and ondansetron failed to reach the predefined primary study outcome when compared with ondansetron alone. TRIAL REGISTRATION: Clinicaltrial.gov identifier: NCT01897337.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Postoperative nausea and vomiting Source Type: research