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Old drugs, new tricks: Medications approved for other uses also have antibiotic action

A number of drugs already approved to treat parasitic infections, cancers, infertility and other conditions also show promise as antibiotic agents against staph and tuberculosis infections, according to a new study. Because these agents act against multiple targets within the bacteria, it may be harder for bacteria to develop resistance, say the researchers.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Nguyen T-N, von Seidlein L, Nguyen T-V, et al. The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study. Lancet Infect Dis 2018; 18: 565 –72—In this Article, the lowest parasite densities shown in figure 3 were found to be below the lower limit of accurate quantification of the PCR method used in the study (22 parasites per mL). The analysis was therefore redone after excluding these low parasite densities.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Tags: Corrections Source Type: research
The Global Fund's decision to withdraw from North Korea is jeopardising tuberculosis control in the country. Talha Burki reports.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research
Conclusions: VL still affects children in our area. Fever, splenomegaly, anemia and appetite loss are the typical findings in children. Noninvasive techniques (immunofluorescent antibody test, rK39) in combination with bone marrow microscopy are useful in the diagnosis of pediatric VL.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Background: Globally, diarrhea kills almost 1500 children daily. In diagnostics, molecular methods are replacing traditional assays. We aimed to investigate enteropathogens in children with and without diarrhea in Luanda, the capital of Angola. Methods: One hundred and ninety-four stool samples from 98 children with acute diarrhea and 96 children without diarrhea were investigated for 17 enteropathogens with multiplex real-time polymerase chain reaction. Results: The median age of children was 10.5 months. Enteropathogens, bacteria, viruses and parasites were detected in 91%, 78%, 50% and 25%, respectively. A posit...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Conclusion: Evidence for optimal treatment options for HIV/TB coinfected children is limited. As the global community strives to reach the fast-track HIV treatment targets and eliminate childhood TB deaths, it must ensure that coinfected children are included in key treatment studies and expand this neglected but crucial area of research.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: HIV Reports Source Type: research
No abstract available
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: ESPID Reports and Reviews Source Type: research
As everyone knows, early diagnosis brings the best chance of fighting cancer. At ETH Zurich, a Swiss technical university, researchers genetically modified skin cells to produce a tattoo that makes itself visible only when the person wearing it has s...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Oncology Source Type: blogs
Authors: Verburg F, Maeder U, Giovanella L, Luster M, Reiners C Abstract BACKGROUND: Neck ultrasound (NUS) is currently seen as a main component of follow-up of differentiated thyroid cancer (DTC) and is usually performed regardless of non-stimulated thyroglobulin (Tg) levels. The aim of this study is to determine whether there is a clinical benefit from such a routine NUS in DTC patients. METHODS: We performed a retrospective database study of 3176 cervical ultrasound exams performed in 773 patients between June 15, 1996 and July 1, 2012. The assessement of the accuracy of ultrasound results was assessed based...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Authors: Nabhan F, Porter K, Lupo M, Randolph GW, Patel KN, Kloos RT Abstract BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies. METHODS: We searched PubMed throu...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
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