Old drugs, new tricks: Medications approved for other uses also have antibiotic action

A number of drugs already approved to treat parasitic infections, cancers, infertility and other conditions also show promise as antibiotic agents against staph and tuberculosis infections, according to a new study. Because these agents act against multiple targets within the bacteria, it may be harder for bacteria to develop resistance, say the researchers.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. KarakiewiczAbstractCytoreductive radical prostatectomy (CRP) may offer a survival advantage, according to several retrospective analyses. However, few data are available regarding the morbidity of radical prostatectomy in the metastatic setting. We addressed intra- and postoperative complications of CRP relative to radical prosta...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Ilaria Cavarretta, Nicasio Mancini, Andrea Salonia
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Atiqullah Aziz, Matthias May, Oliver W. Hakenberg, Sabine D. Brookman-May
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONThe significance of BDR for pT2 or higher advanced GBC without biliary infiltration was equivocal because the patients received no survival benefit by undergoing BDR.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: European Journal of Surgical OncologyAuthor(s): Maria Anna Smolle, Michael Parry, Lee Jeys, Seggy Abudu, Robert GrimerAbstractObjectivesSynovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series.The main emphasis of this study was to determine differences between children and adults and to investigate prognostic factors regarding cancer specific survi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionTPE is an invasive treatment for rectal cancer with high 30-day mortality in elderly patients. Oncological outcomes are similar in elderly and younger patients. Therefore, TPE should not be withheld because of high age only, but careful patient selection is needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe nomograms were able to more accurately predict 3- and 5-year OS and CSS of patients with GISTs than were existing models.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Sanjeevan Muruganandan, Maree Azzopardi, Deirdre B Fitzgerald, Ranjan Shrestha, Benjamin C H Kwan, David C L Lam, Christian C De Chaneet, Muhammad Redzwan S Rashid Ali, Elaine Yap, Claire L Tobin, Luke A Garske, Phan T Nguyen, Christopher Stanley, Natalia D Popowicz, Christopher Kosky, Rajesh Thomas, Catherine A Read, Charley A Budgeon, David Feller-Kopman, Nick A MaskellSummaryBackgroundIndwelling pleural catheters are an established management option for malignant pleural effusion and have advantages over talc slurry pleurode...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Publication date: Available online 20 July 2018Source: Diagnostic and Interventional ImagingAuthor(s): P. Kong, L. Chen, X. Shi, H. Pan, M. Yu, H. Ge, J. Zhu, G. Ma, L. Li, Q. Ding, W. Zhou, S. WangAbstractPurposeTo evaluate the mechanism for enhancing cell death induced by microwave ablation (MWA) combined with doxorubicin treatment in breast cancer cells.Materials and methodsDifferent temperatures of heat treatment were used to mimic the tumor affected by sublethal heat during MWA in vitro. Breast cancer cells were treated at 43 °C and 45 °C, with or without doxorubicin. Cell viability, apoptosis, and i...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
In the past two decades of practicing emergency medicine, there are probably only two major conditions that seem to have markedly increased in my practice: the number of elderly patients we care for and the number of patients with cancer (in their current or  past history) that we care for. The increase in elderly patients in our practice has been strongly addressed in recent years in educational conferences, textbooks and journals, and national guidelines. But cancer still seems to be a relatively ignored clinical condition in emergency medicine.
Source: Emergency Medicine Clinics of North America - Category: Emergency Medicine Authors: Tags: Foreword Source Type: research
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