$1 million gift will support UCLA research on advanced lung disease

Philanthropists Michael and Linda Keston have made a gift of $1 million to the Division of Pulmonary and Critical Care Medicine at the David Geffen School of Medicine at UCLA. The donation will support research into advanced lung disease and the UCLA Lung Health Research Initiative, which was launched in November. The initiative is focused on developing new treatments for lung disease and finding a way to prevent the body from rejecting donor organs — a major challenge for people who have received organ transplants. “The Kestons’ contribution will enable our faculty to pursue innovative research that will eventually lead to new treatments to the benefit of countless patients,” said Dr. John Mazziotta, vice chancellor of UCLA Health Sciences and CEO of UCLA Health. The gift will support a five-year study by the division of pulmonary and critical care medicine to investigate the molecular mechanisms involved in chronic organ transplant rejection. The research will focus on the function of chemokines, proteins that send signals that stimulate cells to attack a foreign body such as a transplanted organ. The subject is a key question in organ transplant medicine because long-term survival after a transplant largely depends on preventing the body’s immune response from treating the new organ as a harmful foreign object. UCLA researchers hope that a clearer understanding of chronic organ rejection will ultimately enable transplant patients to live longe...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study the effect of NMP perfusion fluid on survival, metabolism and function of thawed cryopreserved human (h)MSC and porcine (p)MSC in suspension conditions was studied. Suspension conditions reduced the viability of pMSC by 40% in both perfusion fluid and culture medium. Viability of hMSC was reduced by suspension conditions by 15% in perfusion fluid, whilst no differences were found in survival in culture medium. Under adherent conditions, survival of the cells was not affected by perfusion fluid. The perfusion fluid did not affect survival of fresh MSC in suspension compared to the control culture medium. The f...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
One of the most promising strategies to increase organ donation is the use of organs from donors with Hepatitis C (HCV). We evaluated the safety of transplanting NAT+HCV donors into non-infected lung recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 136 Source Type: research
Heart donation after circulatory death (DCD) has significantly improved organ utilisation with promising early outcomes. To date, adult DCD heart programmes have relied largely on ex-situ heart perfusion during transport of the donor organs even after normothermic regional perfusion (NRP) in the donor where the heart is formally assessed after circulatory arrest. In this pre-clinical porcine study we compare the use of cold storage as an alternative to ex-situ heart perfusion following NRP.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 591 Source Type: research
Evaluation of a potential lung graft in an ex-vivo lung perfusion (EVLP) system has gained an increased use among transplantation centers. Current standard of organ assessment before transplantation with machine perfusion are performed with normothermic temperature but sub-normothermic setting is under clinical use among several solid organs. Our aim was to investigate the impact of sub-normothermic EVLP from donation after circulatory death donor lungs in a rat model.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 573 Source Type: research
This article reviews the organ allocation philosophy focusing on the case of lung transplantations in Brazil.RESUMO A filosofia da aloca ção de órgãos é resultado de duas vertentes aparentemente inconciliáveis: utilitarismo e justiça distributiva. O processo de doação e transplante de órgãos no Brasil revela grandes desigualdades entre regiões e unidades da federação, desde a captação de órgãos até o implante dos ó rgãos. Nesse contexto, o transplante de pulmão é r...
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Human body is intertwined collection of lives of Individual organs.We believe death occurs when brain dies , respiration stops and circulation ceases . Curiously ,when life ends , these organs  don’t die as a single unit . These three events can happen in any of the six possible permutations.Each organ takes different times to die after loss of life.It is like a crashed computer , where the mother board /RAM memory may be transferred to another and be functional . Out of these three , heart function appears to be supreme as it can function without the need of brain (Science of brain-death) and keep the body...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Heart transplantation donor heart transport transmedics Source Type: blogs
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System An Interview with a Programmed Aging Theorist An Interview with Reason at the Life Extension Advocacy Foundation An Interview on Mitochondrial Damage and Dysfunction in Aging An Interview with Vadim Gladyshev on Research into the Causes of Aging An Interview with Jim Mellon, and Update on Juvenescence A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation An Interview with Peter de Keize...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
CONCLUSIONS Management by dedicated intensivists will improve not only the number of actual organ donors, but also the number of harvested organs. PMID: 30510153 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
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