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$1 million gift will support UCLA research on advanced lung disease

Philanthropists Michael and Linda Keston have made a gift of $1 million to the Division of Pulmonary and Critical Care Medicine at the David Geffen School of Medicine at UCLA. The donation will support research into advanced lung disease and the UCLA Lung Health Research Initiative, which was launched in November. The initiative is focused on developing new treatments for lung disease and finding a way to prevent the body from rejecting donor organs — a major challenge for people who have received organ transplants. “The Kestons’ contribution will enable our faculty to pursue innovative research that will eventually lead to new treatments to the benefit of countless patients,” said Dr. John Mazziotta, vice chancellor of UCLA Health Sciences and CEO of UCLA Health. The gift will support a five-year study by the division of pulmonary and critical care medicine to investigate the molecular mechanisms involved in chronic organ transplant rejection. The research will focus on the function of chemokines, proteins that send signals that stimulate cells to attack a foreign body such as a transplanted organ. The subject is a key question in organ transplant medicine because long-term survival after a transplant largely depends on preventing the body’s immune response from treating the new organ as a harmful foreign object. UCLA researchers hope that a clearer understanding of chronic organ rejection will ultimately enable transplant patients to live longe...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Multi-organ retrieval from donation after circulatory determined death (DCD) donors is demanding and requires close collaboration between cardiothoracic and abdominal retrieval teams. Retrieval of DCD hearts for transplantation commenced in the UK in February 2015 and potentially adds challenge to an already demanding situation. We sought to assess the impact of DCD heart retrieval on overall donor organ utilisation in the UK and post-transplant outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Donation after circulatory determination of death (DCD) is a growing source of organs in abdominal and lung transplantation but has been avoided for heart transplantation due to risks of injury associated with uncontrolled warm ischemic arrest. Ex-vivo heart perfusion with the Organ Care System (OCS) provides a unique opportunity to assess the function and metabolic profile of hearts from DCD donors. We tested the hypothesis that OCS may actually promote recovery from ischemic injury with a goal to demonstrating the feasibility of this approach for use in DCD cardiac donors in the United States.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
ual O, Osés Munarriz I Abstract Donation after circulatory death (Maastricht type III donation) or controlled cardiac death refers to the retrieval of organs for transplantation purposes following death confirmed using circulatory criteria after the withdrawal of life support. The persistent shortfall in organ availability has prompted the development of donation programs following circulatory death for lung transplantation. The combined thorax-abdomen extraction in these cases is carried out in only twelve centres in Spain, while the combined use of abdominal normothermic regional perfusion (NRP) is even m...
Source: Anales del Sistema Sanitario de Navarra - Category: General Medicine Authors: Tags: An Sist Sanit Navar Source Type: research
n C Abstract AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
During 2017, the number of deceased organ donors in the United States topped 10,000 for the first time, according to preliminary data from United Network for Organ Sharing (UNOS), which serves as the national Organ Procurement and Transplantation Network (OPTN) under federal contract.  For the year, organs were recovered from 10,281 donors, representing a 3.1 percent increase over 2016 and an increase of 27 percent since 2007. A total of 34,768 organ transplants were performed in 2017 using organs from both deceased and living donors, according to preliminary data. This total is a 3.4 percent increase over 2016 and ma...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
Purpose of review The global shortage of organ donors will not be resolved solely by relying on deceased donation following a brain death determination (DBD). Expansion of deceased donation after circulatory death (DCD) will be needed to address the shortfall of organs for transplantation. Approximately 120 000 organ transplants are performed each year; however, the WHO estimates that this number of transplants only resolves 10% of the annual worldwide transplant need. Recent findings The report addresses the opportunity of DCD expansion by evaluating the DCD potential that is not being realized, the utility of DCD ...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: COMPLICATIONS IN KIDNEY TRANSPLANTATION: Edited by Francis L. Delmonico Source Type: research
Abstract PURPOSE OF REVIEW: The global shortage of organ donors will not be resolved solely by relying on deceased donation following a brain death determination (DBD). Expansion of deceased donation after circulatory death (DCD) will be needed to address the shortfall of organs for transplantation. Approximately 120 000 organ transplants are performed each year; however, the WHO estimates that this number of transplants only resolves 10% of the annual worldwide transplant need. RECENT FINDINGS: The report addresses the opportunity of DCD expansion by evaluating the DCD potential that is not being realized,...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
In this study, we integrated atomic force microscopy (AFM) and molecular approaches to determine whether increased stiffness of aortic VSMCs in hypertensive rats is ROCK-dependent, and whether the anti-hypertensive effect of ROCK inhibitors contributes to the reduction of aortic stiffness via changing VSMC mechanical properties. Despite a widely held belief that aortic stiffening is associated with changes in extracellular matrix proteins and endothelial dysfunction, our recent studies demonstrated that intrinsic stiffening of aortic VSMCs, independent of VSMC proliferation and migration, is an important contributo...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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