Clinical evaluation of the effects of supplementation with curcuminoids on serum fetuin-B concentrations in obese subjects

Abstract Fetuin-B is an emerging negative acute phase protein, and its expression is inversely associated with inflammation. The present study aimed to assess the impact of supplementation with curcuminoids, as naturally occurring polyphenols with anti-inflammatory properties, on circulating concentrations of fetuin-B. In this randomized double-blind trial, 30 obese dyslipidemic subjects received curcuminoids (1 g/day) and matching placebo. The trial had a 2 × 2 crossover design, in which treatment duration with either of the allocations was 4 weeks, intermitted by a 2-week washout period. Serum fetuin-B concentrations were determined at the end of each treatment period. The groups were comparable regarding baseline demographic characteristics and serum fetuin-B concentrations. Supplementation with curcuminoids did not significantly change serum fetuin-B levels compared with placebo (p > 0.05). Serum fetuin-B levels were not found to be correlated with lipid profile parameters nor C-reactive protein in either curcuminoids or placebo groups (p > 0.05). Four-week supplementation with curcuminoids in obese subjects has no significant effect on circulating fetuin-B concentrations.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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We examined US sensitivity for diagnosis of HCC in obese patients. Methods: Liver transplant patients data with HCC in explant was used (January 2012-December 2017). All patients underwent liver US within 3 months of diagnosis of HCC. Number/size of HCC lesions were extracted from radiologic and pathologic reports. Obesity was defined as BMI ≥30 kg/m2. Results: One hundred sixteen patients were included. 80% were male, with mean BMI of 31 kg/m2. The most common underlying liver disease was hepatitis C virus (62%). At the time of diagnosis, median number of HCC lesions was 2 (interquartile range [IQR], 1-3), and ...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
ConclusionsTaken together, these results illustrate a new model in which Purβ functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsLack of ALX/FPR2 induced obesity, reduced the lifespan, amplified leukocyte dysfunction, and facilitated profound inter-organ non-resolving inflammation. Our study shows the integrative and indispensable role of ALX/FPR2 in lipid metabolism, cardiac inflammation-resolution processes, obesogenic aging, and renal homeostasis.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 15 November 2019Source: NeuroscienceAuthor(s): Clarissa M. Liu, Elizabeth A. Davis, Andrea N. Suarez, Ruth I. Wood, Emily E. Noble, Scott E. KanoskiAbstractCentral oxytocin potently reduces food intake and is being pursued as a clinical treatment for obesity. While sexually dimorphic effects have been described for the effects of oxytocin on several behavioral outcomes, the role of sex in central oxytocin modulation of feeding behavior is poorly understood. Here we investigated the effects of sex, estrous cycle stage, and female sex hormones (estrogen, progesterone) on central oxytocin-me...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: December 2019Source: Preventive Medicine, Volume 129Author(s): James F. Sallis, Nisha Botchwey, Myron F. Floyd, Keshia M. Pollack Porter, M. Renée Umstattd Meyer, J. Aaron Hipp, Anna Kim, Terry L. ConwayAbstractThis guest editorial introduces the rationale and goals of the Physical Activity Research Center. It provides an overview of the five papers in this Special Section plus six commissioned studies intended to inform advocacy efforts.
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Objectives: To determine factors associated with nerve injury after acetabulum fracture and to evaluate recovery and outcomes. Design: Retrospective cohort study. Setting: Level 1 trauma center. Patients and Participants: Nine hundred seventy-five skeletally mature patients with acetabulum fracture. Intervention: Operative and nonoperative management. Main Outcome Measurements: Nerve injuries, categorized as traumatic or iatrogenic, recovery (none, partial, or complete), and patient-reported functional outcomes with the Musculoskeletal Function Assessment (n = 353, 36.2%). Results: Thirty-two patients (...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
ConclusionsHemodialysis patients with central obesity, as measured by the A/G ratio, had less favorable plasma lipid profiles and higher levels of inflammation but not an increased risk of ASCVD.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This article describes a simplified technique of endoscopic sleeve gastroplasty using the OverStitch suturing device.
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Source Type: research
Publication date: Available online 25 October 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Lori-Ann Oliver, Jodi-Ann Oliver, Sargis Ohanyan, William Park, Aharon Benelyahoo, Nalini VadiveluPeripheral venous access is perhaps the most commonly performed procedure in hospitals, urgent care, or surgical centers across the country. The ability to obtain peripheral intravenous (IV) access, and in a timely manner, is arguably one of the most important skill sets to be mastered by health care professionals. While skill and experience play a role in successful and timely vascular access, numerous pati...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
CONCLUSION: Sweet drink consumption among preschool-age children is influenced by multiple factors across all domains of the socio-ecological model. Parents and grandparents are calling for education, healthy environments and supportive policies. SO WHAT?: Contrary to common rhetoric, children's sweet drink consumption is often influenced by factors beyond parental control. A multi-component strategy is required to support parents and grandparents in their efforts to make healthy choices for their children. PMID: 31724247 [PubMed - as supplied by publisher]
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
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