Febuxostat Prevents Renal Interstitial Fibrosis by the Activation of BMP-7 Signaling and Inhibition of USAG-1 Expression in Rats.

CONCLUSION: Febuxostat was able to attenuate RIF caused by UUO, which was associated with the activation of BMP-7-Smad1/5/8 pathway and the inhibition of USAG-1 expression in the kidneys of UUO rats.
PMID: 26680283 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - December 18, 2015 Category: Urology & Nephrology Authors: Cao J, Li Y, Peng Y, Zhang Y, Li H, Li R, Xia A Tags: Am J Nephrol Source Type: research