Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression.

CONCLUSION: Stress induces p38K phosphorylation/activation in the hippocampus and thereby reduces neurogenesis and induces depression-like symptoms, events that are prevented by antidepressants via inhibition of the acid sphingomyelinase/ceramide system. PMID: 26682751 [PubMed - as supplied by publisher]
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research

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Authors: Conwell Y PMID: 31964547 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
In New Research Poster 5.4, “Variation in Rates of Intentional Ingestion of Substances for Suspected Suicide Attempts and Substance Abuse Based on Age Among Us Adolescents and Adults,” published in the October 2019 Scientific Proceedings supplement issue of the Journal of the American Academy of Child and Adolescent Psychi atry, (2019;58:S246), the greater than or equal to symbol (≥) was incorrectly reversed by authors in the original publication to show a less than or equal to symbol (≤). This typographical error did not impact the science as reported and the authors regret this error.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Tags: Correction Source Type: research
Authors: Rodríguez-Rodríguez V, Pérez-Garín D, Recio-Saboya P, Rico-Gómez A Abstract During the economic crisis, developed countries have experienced financial fraud, with effects on the physical and mental health of the people affected, and on social domains. Based on the theoretical framework in literature reviews and in quantitative studies, this paper aims to obtain evidence on the effects of financial fraud on health and on the family and social environments of those affected. An intentional sample of 32 people affected by abusive and multi-currency mortgages, preferred and s...
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
This report from CDC provides suicide rates by industry and occupation for 32 states in 2016 with workers in the Construction and Extraction occupations experiencing the highest suicide rates.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Injury Prevention MMWR Morbidity & Mortality Weekly Report Suicide Source Type: news
ConclusionLack of knowledge regarding the causes of death and careless attitude towards the suicidal behavior and, the health and welfare of detainees are avoidable reasons for custody-related deaths.
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
BACKGROUND: Suicide is a global public health problem which has significant negative influence on individuals, families and the society. The aim of this study is to investigate the prevalence of suicidal ideation and related factors among elderly people in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
OBJECTIVE: To assess the association between specific heart diseases and suicide. DESIGN: Nationwide retrospective cohort study. PARTICIPANTS: 7 298 002 individuals (3 640 632 males and 3 657 370 females) aged>15 years and living in Denmark during...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Clinicians are increasingly recognizing the utility of clinical screening, informed patient conversations, and counseling about safe firearm storage to reduce firearm injury and death (1). But preventing firearm-related injury and death requires pragma...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Use of social media by people with mental health problems, and especially those who are prone to self-harm, has potential advantages and disadvantages. This poses a dilemma about how and by how much the form and content of social media sites should be regu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
The risk of suicide is significant during the transition of care; the highest in the first few weeks after discharge from a healthcare facility. This systematic review summarizes the evidence for interventions providing care during this high-risk period. I...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
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