Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression.

CONCLUSION: Stress induces p38K phosphorylation/activation in the hippocampus and thereby reduces neurogenesis and induces depression-like symptoms, events that are prevented by antidepressants via inhibition of the acid sphingomyelinase/ceramide system.
PMID: 26682751 [PubMed - as supplied by publisher]

Source: Neuro-Signals - December 19, 2015 Category: Neurology Authors: Grassmé H, Jernigan PL, Hoehn RS, Wilker B, Soddemann M, Edwards MJ, Müller CP, Kornhuber J, Gulbins E Tags: Neurosignals Source Type: research