Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population.

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population. Bosn J Basic Med Sci. 2015;15(1):67-72 Authors: Satilmis S, Celik O, Biyik I, Ozturk D, Celik K, Akın F, Ayca B, Yalcin B, Dagdelen S Abstract Evidence suggests that low 25-OH vitamin D 25(OH)D concentrations may increase the risk of several cardiovascular diseases such as hypertension, peripheral vascular disease, diabetes mellitus, obesity, myocardial infarction, heart failure and cardiovascular mortality. Recent studies suggested a possible relationship between vitamin D deficiency and increased carotid intima-media wall thickness and vascular calcification. We hypothesized that low 25(OH)D may be associated with coronary atherosclerosis and coronary plaque burden and composition, and investigated the relationship between serum vitamin D levels and coronary atherosclerosis, plaque burden or structure, in young adult patients by using dual-source 128x2 slice coronary computed tomography angiography (CCTA). We included 98 patients with coronary atherosclerosis and 110, age and gender matched, subjects with normal findings on CCTA examinations. Patients with subclinical atherosclerosis had significantly higher serum total cholesterol, triglycerides, hs-CRP, uric acid, HbA1c and creatinine levels and lower serum 25(OH)D levels in comparison with controls. There was no significant correlation bet...
Source: Bosnian Journal of Basic Medical Sciences - Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research