Effect of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights on the Pathogenic Mechanisms of Asbestos-Related Diseases

Conclusions: Our findings suggest that chrysotile asbestos induces EMT, a common event in asbestos-related diseases, at least in part by eliciting the TGF-β-mediated Akt/GSK-3β/SNAIL-1 pathway. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Gulino GR, Polimeni M, Prato M, Gazzano E, Kopecka J, Colombatto S, Ghigo D, Aldieri E. Effect of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights on the Pathogenic Mechanisms of Asbestos-Related Diseases. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409627 Received: 19 December 2014 Accepted: 30 November 2015 Advance Publication: 18 December 2015 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehp508@niehs.nih.gov. Our staff will work wi...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research