A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases
Conclusions: Our systems biology approach allowed identification of converging pathways leading to activation of common targets downstream. To our knowledge, this is the first study to propose an integrated global set of step-by-step molecular mechanisms for a combination of 3 common POPs, using a systems biology approach, which may link POPs exposure to diseases. Experimental evaluation of the proposed pathways may lead to development of predictive biomarkers of POPs’ effects, which could translate into disease prevention and more effective clinical treatment strategies.
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Citation: Ruiz P, Perlina A, Mumtaz M, Fowler BA. A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510308
Received: 5 June 2015
Accepted: 10 December 2015
Advance Publication: 18 December 2015
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research
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