A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases

Conclusions: Our systems biology approach allowed identification of converging pathways leading to activation of common targets downstream. To our knowledge, this is the first study to propose an integrated global set of step-by-step molecular mechanisms for a combination of 3 common POPs, using a systems biology approach, which may link POPs exposure to diseases. Experimental evaluation of the proposed pathways may lead to development of predictive biomarkers of POPs’ effects, which could translate into disease prevention and more effective clinical treatment strategies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Ruiz P, Perlina A, Mumtaz M, Fowler BA. A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510308 Received: 5 June 2015 Accepted: 10 December 2015 Advance Publication: 18 December 2015 Note to readers with disabilities: ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research