SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation.

CONCLUSION: Our study demonstrates that SMAD3 is significantly overexpressed in OA. This overexpression cannot be explained by DNA methylation in the promoter region. The results suggest that the transforming growth factor-β/SMAD3 pathway may be overactivated in OA cartilage and has potential in developing targeted therapies for OA. PMID: 26669923 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26669923?dopt=Abstract

Source: J Rheumatol - December 15, 2015 Category: Rheumatology Authors: Aref-Eshghi E, Liu M, Razavi-Lopez SB, Hirasawa K, Harper PE, Martin G, Furey A, Green R, Sun G, Rahman P, Zhai G Tags: J Rheumatol Source Type: research