Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study [Gynecologic Cancer]
Conclusion
Combined MSI, methylation, and IHC analysis may prove useful in Lynch screening in EC. Twenty-four percent of mutation carriers presented with ECs at age > 60 years, and one carrier had an MSI-positive tumor with no IHC defect. Restricting Lynch testing to women diagnosed at age < 60 years or to women with IHC defects could result in missing a substantial fraction of genetic disease.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Goodfellow, Billingsley, Lankes, Ali, Cohn, Broaddus, Ramirez, Pritchard, Hampel, Chassen, Simmons, Schmidt, Gao, Brinton, Backes, Landrum, Geller, DiSilvestro, Pearl, Lele, Powell, Zaino, Mutch Tags: Combined Modality Gynecologic Cancer Source Type: research
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