Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.

In conclusion, NO signaling probably through neuronal NOS, but not inducible NOS could be involved in the opioid-dependent anticonvulsant effects of chloroquine in this model of seizures in mice. It seems that nitric oxide and opioid systems are involved in modulatory effect of chloroquine on seizures induced by pentylenetetrazol.
PMID: 26655695 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - December 3, 2015 Category: Neurology Authors: Hassanipour M, Shirzadian A, Boojar MM, Abkhoo A, Abkhoo A, Delazar S, Amiri S, Rahimi N, Ostadhadi S, Dehpour A Tags: Brain Res Bull Source Type: research