Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression.

Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression. Curr Pharm Des. 2015 Dec 14; Authors: Watzlawik JO, Wootla B, Rodriguez M Abstract Accumulating evidence demonstrates involvement of tryptophan metabolites and in particular activation of the kynurenine pathway (KP) in neurocognitive disorders under CNS inflammatory conditions. The KP is involved in several brain-associated disorders including Parkinson's disease, AIDS dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, and brain tumors. Our review is an attempt to address any relevant association between dysregulation of KP and multiple sclerosis (MS), an inflammatory CNS disorder that ultimately leads to demyelinated brain areas and severe neurological deficits. Modulation of KP is a new topic for the field of MS and warrants further research. The availability of potential KP modulators approved for MS may shed some light into the therapeutic potential of KP antagonists for the treatment of MS patients. PMID: 26667001 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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Authors: Keenan R, Chepulis L, Ly J, Carter S, Lao C, Asim M, Bhat A, Deo S, Lim KP, Mohammed R, Scarlet S, Lawrenson R Abstract INTRODUCTION Life expectancy in patients with schizophrenia is 15-20 years less than the general population. A dominant cause of morbidity and mortality in these patients is cardiovascular disease. Adverse consequences of modifiable cardiovascular risk factors can be reduced by regular monitoring of metabolic outcomes and intervention if required. AIM To evaluate the metabolic screening in primary care for patients with schizoaffective disorders managed in primary care. To show the useful...
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
Publication date: Available online 1 April 2020Source: Redox BiologyAuthor(s): Zeina El Ali, Anthony Ollivier, Sylvie Manin, Michael Rivard, Roberto Motterlini, Roberta Foresti
Source: Redox Biology - Category: Biology Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09758A, Feature ArticleMadhuparna Roy, Ishita Pal, Arnab K Nath, Somdatta Ghosh Dey The amyloid cascade theory attributes the neurodegeneration observed in Alzheimer ’s disease (AD) to the deposition of amyloid β (Aβ) peptide into plaques and fibrils in the AD brain. The metal... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Purpose of review The universal adoption of electronic health records, improvement in technology, and the availability of continuous monitoring has generated large quantities of healthcare data. Machine learning is increasingly adopted by nephrology researchers to analyze this data in order to improve the care of their patients. Recent findings In this review, we provide a broad overview of the different types of machine learning algorithms currently available and how researchers have applied these methods in nephrology research. Current applications have included prediction of acute kidney injury and chronic kidney d...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
David BoazSigns have popped up all over my neighborhood in Arlington, Virginia, urging us to respond to the census – so that the8th wealthiest county in America won ’t miss out on funding collected from taxpayers across the country.Census Bureau materials stress to local officials that census data will help them get “their fair share of funding” from hundreds of federal programs.Obviously this is a zero‐​sum game. If my neighbors and I all fill out the form, then you and your neighbors will get less from the common federal trough. But at least we ’ll be getting our “fair sh...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Cellular senescence is one of the contributing causes of aging, in the sense that senescent cells accumulate in old tissues. Even when only a tiny fraction of all cells are senescent, their signaling causes chronic inflammation and disruption of tissue function. Senescence is, however, a helpful program when these cells exist only temporarily and are promptly destroyed. The signaling that is so harmful when maintained over the long term aids in wound healing and suppression of cancer when present for a short time only. Since the comparatively recent acceptance of senescent cells as an important cause of aging, the research...
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This article explores live discharge from hospice for caregivers of adults with dementia through a theoretical lens of Symbolic Interactionism (SI) and Attachment Theory (AT). The theories of SI and AT support and assist in understanding the experience of caregivers who lose hospice support due to ineligibility. In addition, caregivers watch the gradual deterioration and psychological loss of someone with dementia while they remain alive described as an ambiguous loss. Ambiguous loss as a subset of traditional bereavement theories provides a framework for this exploration and provides a relevant illustration of the complex...
Source: Journal of Social Work in End-of-Life and Palliative Care - Category: Palliative Care Tags: J Soc Work End Life Palliat Care Source Type: research
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Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
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