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When rejection comes from within

A new cellular structure responsible for previously unexplained rejection of organ transplants has been identified. This discovery could one day revolutionize transplantation practice by modifying risk assessment of rejection in people who receive heart, lung, kidney, or liver transplants.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Renal ischemia-reperfusion injury (IRI) is an inherent process to kidney transplantation. The subsequent release of pro-inflammatory cytokines (e.g., IL-1 β, TNF-α, IL-6) may induce a systemic inflammatory response, resulting in pro-inflammatory cells recruitment and remote organ damage. Several studies have already documented dysfunction of the lung, heart, liver, and brain following renal IRI. The heme oxygenase-1 (HO-1), a stress-responsive enzym e endowed with cytoprotective, antiapoptotic, and immunomodulatory properties, protects kidney from renal IRI when pharmacology induced before ischemia.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Transplantation & Vascular Surgery: Renal Transplantation Vascular Surgery I Source Type: research
Transplant candidates have advanced chronic disease, which often leads to muscular and respiratory impairment contributing to reduced quality of life and daily life activities, and these patients are therefore referred to physiotherapy service. Because of this, it is necessary to know the epidemiologic and functional profile for a better physiotherapeutic approach. Inpatients of kidney, liver, heart, lung and multivisceral transplantation programs were followed up for 1 year. A comparative analysis between groups was performed, taking into account hospital stay time and functional independence measure (FIM).
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Tags: 15th Brazilian Transplantation Congress and 16th Portuguese-Brazilian Transplantation Congress Source Type: research
We report a case of heart-kidney transplantation from an HCV (+) donor to (-) recipient with subsequent infection and clearance with anti-viral therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Multiple listing is common among heart, liver and kidney transplant recipients, with notable decreases in waitlist times and mortality. While multiple listing among lung recipients is not uncommon, temporal trends and regional variation in the current era is poorly understood.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Gender mismatched have poorer outcomes in retrospective single centre studies in the literature for kidneys, hearts and livers. We aim to evaluate the impact of gender mismatch in adults undergoing heart transplantation in the UK.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract BACKGROUND: Serial gene expression profiling (GEP) may reduce the need for endomyocardial biopsies for detecting acute cellular rejection (ACR) after transplantation, but its performance in dual organ transplant recipients is currently unknown. METHODS: We analyzed 18 months of follow-up in a national cohort of 27 dual organ recipients (18 heart-kidney, 8 heart-liver, 1 heart-lung) matched to 54 heart-only recipients for gender, age, and time to first GEP (AlloMap®) test. ACR, antibody-mediated rejection (AMR), cytomegalovirus infections, biopsies, and longitudinal GEP scores were evaluated. ...
Source: Transplant Immunology - Category: Transplant Surgery Authors: Tags: Transpl Immunol Source Type: research
Abstract Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. Here, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further outline the preclinical and clinical studies concerning compounds targeting CTGF in various pathologies with the focus on heart, lung, l...
Source: Matrix Biology - Category: Molecular Biology Authors: Tags: Matrix Biol Source Type: research
Many deceased by neurologic criteria donors are administered inhalational agents during organ recovery surgery —a process that is characterised by warm and cold ischaemia followed by warm reperfusion. In certain settings, volatile anaesthetics (VA) are known to precondition organs to protect them from subsequent ischaemia–reperfusion injury. As such, we hypothesised that exposure to VA during organ procu rement would improve post-graft survival. Lifebanc (organ procurement organisation [OPO] for NE Ohio) provided the investigators with a list of death by neurologic criteria organ donors cared for at three large...
Source: Anaesthesia and Intensive Care - Category: Anesthesiology Source Type: research
More News: Cardiology | Heart | Heart Transplant | Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | Lung Transplant | Science | Transplants | Urology & Nephrology