Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia.

Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia. J Trop Med. 2015;2015:796182 Authors: Tobón-Castaño A, Mesa-Echeverry E, Miranda-Arboleda AF Abstract Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods. 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). Results. Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematologic...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research

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Funding Opportunity RFA-AI-20-064 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support research to advance understanding of the underlying immune mechanisms that contribute to malaria vaccine-elicited protection or vaccine hypo-responsiveness in endemic regions by capitalizing on recent research advances in systems vaccinology and systems immunology as well as emerging opportunities in data science and informatics. Multidisciplinary science and collaboration among investigators from the malaria vaccine research field and other relevant scientific areas are highly encouraged. The goal i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
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Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Case study Source Type: research
Abstract Intermittent preventive treatment in pregnancy (IPTp) with monthly sulfadoxine-pyrimethamine (SP) is recommended for malaria-endemic parts of Africa, but efficacy is compromised by resistance and, in recent trials, dihydroartemisinin-piperaquine (DP) has shown better antimalarial protective efficacy. We utilized blood samples from a recent trial to evaluate selection by IPTp with DP or SP of Plasmodium falciparum genetic polymorphisms that alter susceptibility to these drugs. The prevalence of known genetic polymorphisms associated with altered drug susceptibility was determined in parasitemic samples, in...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
AbstractPurpose of ReviewSequestration ofPlasmodium-infected cells in the placenta causes significant adverse effects on mothers and their fetuses. With progress in understanding placental malaria and associated adverse consequences, this review addresses the situation in an area with high prevalence, in Blue Nile State, Sudan, where protective interventions are not adequately provided.Recent FindingsSeveral studies have confirmed that malaria infection during pregnancy with parasites in the placenta, even at sub-patent level detected by molecular techniques, can result in maternal morbidity, fetal growth restriction, and ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
CONCLUSIONS: BK-SE36/CpG has an acceptable safety profile. Use of CpG-ODN(K3) greatly enhanced immunogenicity in malaria naïve Japanese adults when compared to BK-SE36 alone. The utility of BK-SE36/CpG is currently under evaluation in a malaria endemic setting in West Africa. TRIAL REGISTRATION: JMACCT Clinical Trial Registry JMA-IIA00109. PMID: 33012605 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Contributors : Prasida Holla ; Brian Dizon ; Abhijit A Ambegaonkar ; Noga Rogel ; Ella Goldschmidt ; Arun K Boddapati ; Haewon Sohn ; Dan Sturdevant ; James W Austin ; Lela Kardava ; Li Yuesheng ; Poching Liu ; Susan Moir ; Susan K Pierce ; Asaf MadiSeries Type : OtherOrganism : Homo sapiensHuman chronic infectious diseases have been shown to alter the composition and phenotype of the B cell compartment, which, in part, can attribute to failure to acquire protective immunity. However, the extent of such alterations is poorly understood. Here, using a combination of bulk and single cell RNA-sequencing (scRNA-seq) of B cells...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Contributors : Holla Prasida ; Abhijit A Ambegaonkar ; Noga Rogel ; Arun K Boddapati ; Haewon Sohn ; Dan Sturdevant ; Asaf Madi ; Susan K PierceSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman chronic infectious diseases have been shown to alter the composition and phenotype of the B cell compartment, which, in part, can attribute to failure to acquire protective immunity. However, the extent of such alterations is poorly understood. Here, using a combination of bulk and single cell RNA-sequencing (scRNA-seq) of B cells in individuals living in malaria-endemic Africa, we characte...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Holla Prasida ; Abhijit A Ambegaonkar ; Noga Rogel ; Arun K Boddapati ; Haewon Sohn ; Dan Sturdevant ; Asaf Madi ; Susan K PierceSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman chronic infectious diseases have been shown to alter the composition and phenotype of the B cell compartment, which, in part, can attribute to failure to acquire protective immunity. However, the extent of such alterations is poorly understood. Here, using a combination of bulk and single cell RNA-sequencing (scRNA-seq) of B cells in individuals living in malaria-endemic Africa, we characte...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Abstract Chloroquine remains the first-line treatment for uncomplicated malaria in Haiti, and until recently, sulfadoxine-pyrimethamine was the second-line treatment. A few studies have reported the presence of molecular markers for resistance in Plasmodium falciparum parasites, and in vivo therapeutic efficacy studies (TESs) have been limited. Recognizing the history of antimalarial resistance around the globe and the challenges of implementing TESs in low-endemic areas, the Ministry of Health established a surveillance program to detect molecular markers of antimalarial resistance in Haiti. Sentinel sites were p...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
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Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
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