Assessment of the optimization of the conditions of mitomycin C intravesical instillation completion in the setting of non-muscle invasive bladder cancer treatment.

CONCLUSION: The observance of the instructions regarding urine alkalinization before MMC instillations was satisfactory and has achieved a sufficiently high urinary pH to prevent degradation of the product in 91% of cases. Conversely, the fluid restriction was not followed closely and has not shown its effectiveness on the concentration of urine. LEVEL OF EVIDENCE: 4. PMID: 26653577 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research

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Publication date: Available online 17 September 2019Source: Urology Case ReportsAuthor(s): Lim HC, Khong TL, Ong TA, Roslani AC, Ang CWAbstractBladder perforation secondary to transurethral resection of bladder tumour (TURBT) increases the risk of tumour seeding and eventual extravesicle metastasis. Here we presented a case where a patient with localised bladder tumour was initially managed with repeated TURBT for tumour recurrence. Subsequently he was found to have extravesicle pelvic metastasis. This was likely secondary to microperforation of bladder and tumour seeding. Microscopic bladder perforation is difficult to di...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conclusions: In 3D brachytherapy of cervical cancer, GO and IPSA optimizations do not present a significant difference in target dose coverage; nevertheless, IPSA may reduce the maximum dose to normal tissue when compared with GO. PMID: 31523240 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusions: When the facilities for MR-compatible applicators are not available, MR-based ISBT is feasible with PEEK catheters using available resources for advanced cervical cancer. Doses to HR-CTV and IR-CTV were achieved, restricting doses to OARs as per GEC-ESTRO guidelines. PMID: 31523230 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): A. Fuentes-Bonachera, N.P. Kelly, D. Murray, G. McGuinness, W.P. Shields, I.M. Cullen, P.J. Daly
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): S. O’Meara, S. Considine, S. Anderson, M. Aboelmagd, S. Connolly, D. Galvin, N. Hegarty, K.J. O’Malley
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): N. O’Reilly, F. O’Brien, K. O’Connor
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 September 2019Source: European UrologyAuthor(s): Eugene Shkolyar, Xiao Jia, Timothy C. Chang, Dharati Trivedi, Kathleen E. Mach, Max Q.-H. Meng, Lei Xing, Joseph C. LiaoAbstractAdequate tumor detection is critical in complete transurethral resection of bladder tumor (TURBT) to reduce cancer recurrence, but up to 20% of bladder tumors are missed by standard white light cystoscopy. Deep learning augmented cystoscopy may improve tumor localization, intraoperative navigation, and surgical resection of bladder cancer. We aimed to develop a deep learning algorithm for augmented cystoscopic d...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Programmed cell death 4 (PDCD4) is a tumor suppressor gene implicated in many cellular functions, including transcription, translation, apoptosis, and the modulation of different signal transduction pathways. The downstream mechanisms of PDCD4 have been well-discussed, but its upstream regulators have not been systematically summarized. Noncoding RNAs (ncRNAs) are gene transcripts with no protein-coding potential but play a pivotal role in the regulation of the pathogenesis of solid tumors, cardiac injury, and inflamed tissue. In recent studies, many ncRNAs, especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsPET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Improved antitumor efficacy of neutrophils stimulated by bacillus Calmette‑Guérin. Mol Med Rep. 2019 Jul 25;: Authors: Wang H, Wang D, Feng Y, Zhai J, Lu C Abstract Bacillus Calmette‑Guérin (BCG) has become a significant treatment for bladder cancer, and neutrophils are reported to be associated with the antitumor effect of BCG. The aim of the present study was to clarify the antitumor function of neutrophils stimulated by BCG. Initially, the killing effect and cytotoxic activity of neutrophils treated with BCG was detected. Subsequently, the effectiveness of BCG‑treated neutrophils...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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