New method of diagnosing deadly fungal lung infection in leukemia patients discovered

A new way detect early a potentially deadly fungal infection in patients with suppressed immune systems, such as those being treated for leukemia or have had an organ transplant, has been revealed by a team of scientists.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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AbstractPurpose of the ReviewThis review summarizes data about epidemiology, treatment, and risk factors for invasive fungal infections (IFI) in patients affected by chronic lymphocytic leukemia (CLL), multiple myeloma (MM), and indolent non Hodgkin lymphoma (iNHL).Recent FindingsDespite advances in the prognosis and treatment of hematological malignancies in recent years, susceptibility to infection remains a significant challenge to patient care. A large amount of data regarding patients with acute leukemias have been published while little information is available on incidence of IFI in chronic lymphoproliferative disor...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
ConclusionsWe identified four risk factors-unrelated donor transplantation, smoking, EBMT risk score> 2 and moderate to severe cGVHD to predict IMIs among acute leukemia patients undergoing allo-HSCT. This cohort study suggests early identification of high-risk patients and to provide better prevention strategies would reduce the incidence and severity of IMIs in these patients.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
We report the successful treatment of an adolescent male with B-cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement. The strategies described could be applied to other MDR fungal infections.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
It ’s 1970 and 10-month-old Maurice Elias lay in a hospital bed in the pediatric intensive care unit dangerously malnourished, at just 14 pounds, and with a severe infection in his mouth. The antibiotics that doctors at UCLA had been using to treat Maurice, who had been born without a functional immu ne system, were no longer working.The only way Maurice was going to survive was a bone marrow transplant.“If we couldn't find a way to give Maurice a working immune system, he was going to die. And the only way to do so was with a risky transplant that could be fatal, too,” said Dr. Richard Stiehm, the UCLA d...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Exserohilum rostratum is a rare cause of pediatric cutaneous fungal infections, previously seen in immunocompromised children with leukemia. E. rostratum is a dematiaceous fungus that is found in grass and soil and sometimes marine environments. Here, we present a case of cutaneous phaeohyphomycosis on the right upper extremity caused by E. rostratum in a 3-year-old girl with hemophagocytic lymphohistiocytosis (HLH). Notably, this lesion arose during the course of the patient ’s hospitalization, and initial histology of an incisional biopsy was nonspecific for the invading pathogen.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
In conclusion, incidence of breakthrough IFI was low among patients receiving posaconazole prophylaxis, and not significantly different between patients receiving the tablet versus oral suspension formulations. PMID: 30012757 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00393
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Publication date: April 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 2Author(s): Gu-Lung Lin, Hsiu-Hao Chang, Chun-Yi Lu, Chung-Ming Chen, Meng-Yao Lu, Ping-Ing Lee, Shiann-Tarng Jou, Yung-Li Yang, Li-Min Huang, Luan-Yin ChangAbstractBackgroundInvasive fungal infection (IFI) causes significant morbidity and mortality in patients with hematological malignancies, especially those with acute myeloid leukemia (AML), recurrent acute leukemia, high-risk acute lymphoblastic leukemia, and after allogeneic hematopoietic stem cell transplantation. The study aimed to investigate the clinical charact...
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: April 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 2Author(s): Hirozumi Sano, Ryoji Kobayashi, Daiki Hori, Kenji Kishimoto, Daisuke Suzuki, Kazue Yasuda, Kunihiko KobayashiAbstractBackgroundPediatric patients under treatment for acute myeloid leukemia (AML) are at high risk for invasive fungal infection (IFI). We evaluated the efficacy of prophylactic administration of voriconazole (VRCZ) with two different doses.MethodsBetween October 2005 and June 2011, 17 children and adolescents (aged 0–20 years) undergoing chemotherapy for AML were prophylactically administere...
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy.MethodsAll patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus.ResultsDuring the study period, 236 (11.3%) of 2083 patients with hematological malignancy were diagnosed as pulmonary IFI, including 41 (17.4%) proven, 75 (31.8%) probable, and 120 (50.8%) possible cases. Among the...
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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