Why Is It Called Christmas Disease?

Discussion Too much or too little causes the important homeostatic balance of life to be upset. This is true of the interactions between the circulatory and hematology systems of the body and their important function in ensuring that the circulatory system plumbing is not leaking (i.e. bleeding) and also not getting plugged up (i.e. thrombosis). A healthy system has adequate numbers of functional platelets, and protein synthesis of the factors needed for a balanced hemostasis system. An adequate amount of Vitamin K is needed for some factors activity. Additionally the absence of any drugs that interfere with platelets or the factors (i.e. aspirin, heparin, warfarin, etc.) is needed for a healthy system. If any one of the clotting cascade factors is missing or abnormal, then bleeding can result. Hemophilia A, Hemophilia B and von Willebrand Disease are the most common bleeding disorders with von Willebrand Disease being the most common inherited bleeding disorder overall. The coagulation cascade is naturally a highly regulated system with many parts that is usually divided into 2 pathways that activate a common pathway. Images of the coagulation cascade can be reviewed here. The factors involved are: Intrinsic system – VIII, IX, X, XI, XII Extrinsic system – III, VII Common pathway – I, II, V, X, XIII Factors that are dependent on Vitamin K for activity are – II, VII, IX and X, plus Protein C, Protein S and Protein Z which are regulator proteins Mos...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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ConclusionsAdvances in the neoadjuvant treatment of rectal tumors contributed to better rates of complete pathological responses. New paradigms promote an increase in the complete clinical response rates, which would allow organ preservation and consequent reduction of surgical morbidity.ResumoObjetivoDescrever os resultados parciais de estudo em pacientes com câncer de reto submetidos a tratamento neoadjuvante com quimioterapia e radioterapia quanto à taxa resposta clínica completa, sobrevida livre de doença, função anorretal e qualidade de vida.Material e métodosEstudo pros...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
ConclusionProgramming surgery more than eight weeks after chemoradiotherapy seems preferable to the six to eight weeks most recently practiced, increasing tumor downstaging and having higher complete pathological response rates.ResumoObjetivos do estudoAvaliar o timing ideal entre a terapêutica neoadjuvante e cirúrgica no carcinoma do reto e a sua influência nos outcomes de tratamento.Material e métodosUtilizando a “PubMed”, foi feita uma revisão sistemática da literatura disponível acerca da influência do timing cirúrgico após quimiorradioterap...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
ConclusionsOur results confirm that anticoagulation allows a recanalization of PVT complicating cirrhosis in the majority of the cases, is associated with non-severe bleeding complications, and can be maintained for a long duration in order to avoid recurrence.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Rhea Chouhan, Patel Raveena, Alexander Rickart, Richard Umasuthan, Kaveh Shakib
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Olivia Johnson King, Arpan Tahim, Zaid Sadiq
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Kohmal Solanki, Jag Dhanda
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Anand Kumar, Keith Jones, Sean Mortimore, David Laugharne
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Clare Schilling, Mark McGurk
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Jeremy McMahon, Stuart Hislop, Alice Nicol, Ian McLaughlin, Douglas McLellan, Jim Garvie, Colin MacIver, Craig Wales, Mark Ansell, Ewen Thomson
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: December 2018Source: British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 10Author(s): Dominic Lamont, Mark Cairns, Peter Bujtar, Andrew Carton
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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