Why Is It Called Christmas Disease?
Discussion Too much or too little causes the important homeostatic balance of life to be upset. This is true of the interactions between the circulatory and hematology systems of the body and their important function in ensuring that the circulatory system plumbing is not leaking (i.e. bleeding) and also not getting plugged up (i.e. thrombosis). A healthy system has adequate numbers of functional platelets, and protein synthesis of the factors needed for a balanced hemostasis system. An adequate amount of Vitamin K is needed for some factors activity. Additionally the absence of any drugs that interfere with platelets or the factors (i.e. aspirin, heparin, warfarin, etc.) is needed for a healthy system. If any one of the clotting cascade factors is missing or abnormal, then bleeding can result. Hemophilia A, Hemophilia B and von Willebrand Disease are the most common bleeding disorders with von Willebrand Disease being the most common inherited bleeding disorder overall. The coagulation cascade is naturally a highly regulated system with many parts that is usually divided into 2 pathways that activate a common pathway. Images of the coagulation cascade can be reviewed here. The factors involved are: Intrinsic system – VIII, IX, X, XI, XII Extrinsic system – III, VII Common pathway – I, II, V, X, XIII Factors that are dependent on Vitamin K for activity are – II, VII, IX and X, plus Protein C, Protein S and Protein Z which are regulator proteins Mos...
Natalia Slazak, 31, from Buckinghamshire, was diagnosed with aplastic anaemia, a condition which causes red and white blood cells and platelets to drop to dangerously low levels.
Authors: Goret CC, Goret NE, Ozkan OF, Karaayvaz M Abstract Foreign body reactions may develop against exogenous or certain endogenous materials. Cases of suture granuloma that develop against nonabsorbable suture material are rare complications of thyroid surgery. Because of these postoperative complications, a history of cancer prior to the operation suggests recurrence of cancer. Appropriate clinical, radiological, and pathological evaluation is highly important in such cases. Postoperative foreign bodies may remain undetected for years, but they sometimes cause lethal complications. KEY WORDS: Cancer mimick...
Authors: Mignard X, Antoine M, Moro-Sibilot D, Dayen C, Mennecier B, Gervais R, Amour E, Milleron B, Morin F, Zalcman G, Wislez M Abstract BACKGROUND: Programmed cell death-ligand 1 (PD-L1) is a checkpoint receptor that facilitates immune evasion by tumor cells, through interaction with programmed cell death-1 (PD-1), a receptor expressed by T-cells. Durvalumab is an anti-PD-L1 monoclonal antibody that blocks PD-L1 interaction with PD-1 on T-cells, countering the tumor's immune-evading tactics. Phase I/II studies demonstrated durable responses and manageable tolerability in heavily pre-treated patients with non-sma...
When a patient has an inherited cancer-associated gene, it is desirable, but not easy, to have other family members tested. Using a commercial lab to circumvent nettlesome privacy regulations may help.Medscape Medical News
PANCREATIC cancer doesn ’t have any specific causes, but there are various risk factors which could increase the chance of developing the disease. Having diabetes is one of them.
Authors: Skok P, Kristijan S Abstract Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. The authors present the case of a 22-year-old female patient that was admitted to their hospital due to diarrhea, fever, arthralgias, and diffuse erythematous papu...
THE first UK patient has received radiotherapy using a machine which could one day cure some cancers in a single treatment.
Barry Dolling, 65, from Selsdon in Surrey, has become the first person in the UK to receive radiotherapy treatment from the MR Linac machine at the Royal Marsden in London.
HIGH BLOOD pressure symptoms are rarely noticeable, however they are sometimes present when blood pressure is severely high. Bleeding from a particular part of the body could indicate what is known as ‘malignant hypertension’.
PMID: 30243508 [PubMed - in process]
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