Strategies for developing new antiviral flu drugs

New analysis of the influenza A virus by scientists at the University of Hertfordshire shows potential for developing new anti-viral drugs which are more likely to be universally effective against the flu virus originating from avian, swine or human virus strains.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news

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r Lal Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and endocytosis had remained elusive until now. In the present study, we observed co-localization of IAV with a lipid raft marker ganglioside, GM1, on the host surface. Further, we isolated the lipid raft micro-domains from IAV infected cells and detected IAV protein in the raft fraction. Finally, raft disruption using Methyl-β-Cyclodextrin revealed significant r...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Mice were immunized intramuscularly with HA-M1, NA-M1 or M1 VLPs and protective immunity was evaluated by assessing lung virus loads against low (5LD50) or high (100LD50) lethal dose of homologous virus challenges. High levels of virus-specific serum IgG antibody responses were induced in mice after HA-M1 VLPs immunization, whereas low or no IgG antibody responses were detected from immunization with NA-M1 VLPs or M1 VLPs, independently. Mice that were immunized with HA-M1 VLPs showed below...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ConclusionsThe current study indicates that a history of OSAS/CSAS, myocardial infarction and BMI > 30 might be related to ICU admission in influenza patients. Second, ICU patients develop more pulmonary co-infections. Last, (pre-existent) renal failure and diabetes mellitus are more often observed in non-survivors.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Publication date: Available online 16 November 2018Source: Veterinary MicrobiologyAuthor(s): Xiaohong Xu, Cong Xue, Renfu Yin, Xinxin Liu, Junjiao Li, Yidong Fei, Zhe Liu, Jiaqi Mu, Yuhai Bi, Tobias Stoeger, Jing Qian, Zhuang DingAbstractNewcastle disease virus (NDV) and H9 subtype avian influenza virus (AIV) are two avian pathogens across the globe. Inasmuch as most poultry flocks worldwide are vaccinated with a live low-virulence or attenuated NDV vaccine, we embarked on the development of vaccine prototypes that would have dual specificities and would allow a single immunization against both avian influenza (AI) and New...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 November 2018Source: Veterinary MicrobiologyAuthor(s): Juanhua Liu, Xiaohui Mu, Xiaobo Wang, Haixia Huan, Qingqing Gao, Juan Chen, Peizhuang Qiao, Luyao Jiang, Song Gao, Xiufan LiuAbstractThe lambda red recombination system makes it suitable for screening virulence gene utility in avian pathogenic Escherichia coli (APEC) on account of its wide applicability, simplicity and high efficiency. In APEC E058 (O2 serogroup), there are two copies of the outer membrane protease (ompT) gene, compT encoding cOmpT that is located on the chromosome and pompT encoding pOmpT that is located on a ColV...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 November 2018Source: BiologicalsAuthor(s): Ismaila Shittu, Adeyinka J. Adedeji, Pam D. Luka, Olayinka O. Asala, Nancy M. Sati, Ijeoma O. Nwagbo, Chinonyerem N. Chinyere, Oluwadamilola O. Arowolo, Jolly A. Adole, Paulinus Emennaa, Paul A. Abdu, Tony M. JoannisAbstractGlobally, vaccines are used to prevent and control the menace of infectious diseases in livestock with some reported to be inadvertently contaminated with extraneous agents (EAs). With the aim of screening and characterizing for some selected EAs, 44 live viral poultry vaccines were randomly selected based on availability. ...
Source: Biologicals - Category: Biology Source Type: research
We refer transmission of infections in India which have implications for Pakistan [1]. As compared to Pakistan, the range and burden of infectious diseases are enormous in India including Severe Acute Respiratory Syndrome (SARS) contagion in 2002 –2003, Influenza A virus epidemic of 2006 (avian influenza), 2007 Equine influenza, Swine flu pandemic outbreaks in 2009 and 2014 [2]. Moreover, episodes of infectious diseases continue to rise in India, with a recent surge of chikungunya and dengue cases in 2016 [1].
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
The Zika virus attracted many headlines this winter, but a recent admission by the chief medical officer at a leading vaccine manufacturer -- that the world is ill-prepared to deal with pandemic outbreaks -- underscores a fundamental problem. To ensure safety and efficacy, the federal government's regulatory approval process for new vaccines may extend development timelines for years. So when The New York Times reports that "eighteen organizations are working on developing a vaccine for the Zika virus," it is likely that those companies will labor for a very long time. Vaccinations rightly require stri...
Source: Science - The Huffington Post - Category: Science Source Type: news
Abstract: History provides us several illustrations where epidemic outbreaks have led to biological disasters. Accidental or deliberate release of harmful micro-organisms can also lead to biological disasters. With the advent of bio-terrorism, there is a growing realisation that biological agents can also be used as weapons of mass destruction. The spread of Spanish Influenza of 1917-18, the Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS), Severe Acute Respiratory Syndrome (SARS), Swine Flu (H1N1), Avian Influenza (H5N1), Middle East Respiratory Syndrome (MERS), dengue, chikunguniya, Ebola o...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
Conclusions: By referring to the previous studies, we suggest that proteins including FAN, CPSF2, AGO1, AGO2, PAX5, STAT1 and PDGFB can be used as therapeutic targets of IAV infection.J Mol Microbiol Biotechnol 2015;25:311-319
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
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