Strategies for developing new antiviral flu drugs

New analysis of the influenza A virus by scientists at the University of Hertfordshire shows potential for developing new anti-viral drugs which are more likely to be universally effective against the flu virus originating from avian, swine or human virus strains.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news

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ConclusionsThis Phase I trial showed the MDCK-derived H5N1 candidate vaccine is safe and immunogenic. The source of RBCs has a significant impact on the measurement of HAI titers (ClinicalTrials.gov number: NCT01675284.).
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
CONCLUSION: ANE is a distinctive type of acute encephalopathy with diverse clinical spectrum. Even though the diagnostic criteria are available, they might not be watertight. In addition, treatment options are still limited. Further studies for better outcome are needed. PMID: 31099193 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
Publication date: Available online 17 May 2019Source: Preventive MedicineAuthor(s): Jessica L. Gleason, Amelia Jamison, Vicki S. Freimuth, Sandra Crouse QuinnAbstractRacial disparities in influenza vaccination persist between African American and White adults. It is critical to explore the reasons behind this disparity, which may be linked to the use of “folk” or home remedies for illness prevention and treatment. For this study, The GfK Group was contracted to conduct a nationally-representative survey (n = 819 African American and 838 White respondents). Respondents were asked about behaviors, attitudes, ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Sandhya Bangaru, Shanshan Lang, Michael Schotsaert, Hillary A. Vanderven, Xueyong Zhu, Nurgun Kose, Robin Bombardi, Jessica A. Finn, Stephen J. Kent, Pavlo Gilchuk, Iuliia Gilchuk, Hannah L. Turner, Adolfo García-Sastre, Sheng Li, Andrew B. Ward, Ian A. Wilson, James E. CroweSummaryHere, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 he...
Source: Cell - Category: Cytology Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Akiko Watanabe, Kevin R. McCarthy, Masayuki Kuraoka, Aaron G. Schmidt, Yu Adachi, Taishi Onodera, Keisuke Tonouchi, Timothy M. Caradonna, Goran Bajic, Shengli Song, Charles E. McGee, Gregory D. Sempowski, Feng Feng, Patricia Urick, Thomas B. Kepler, Yoshimasa Takahashi, Stephen C. Harrison, Garnett KelsoeSummaryVaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led u...
Source: Cell - Category: Cytology Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Yan Wu, George F. GaoA universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host &Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer “breathing.”
Source: Cell - Category: Cytology Source Type: research
We refer transmission of infections in India which have implications for Pakistan [1]. As compared to Pakistan, the range and burden of infectious diseases are enormous in India including Severe Acute Respiratory Syndrome (SARS) contagion in 2002 –2003, Influenza A virus epidemic of 2006 (avian influenza), 2007 Equine influenza, Swine flu pandemic outbreaks in 2009 and 2014 [2]. Moreover, episodes of infectious diseases continue to rise in India, with a recent surge of chikungunya and dengue cases in 2016 [1].
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
The Zika virus attracted many headlines this winter, but a recent admission by the chief medical officer at a leading vaccine manufacturer -- that the world is ill-prepared to deal with pandemic outbreaks -- underscores a fundamental problem. To ensure safety and efficacy, the federal government's regulatory approval process for new vaccines may extend development timelines for years. So when The New York Times reports that "eighteen organizations are working on developing a vaccine for the Zika virus," it is likely that those companies will labor for a very long time. Vaccinations rightly require stri...
Source: Science - The Huffington Post - Category: Science Source Type: news
Abstract: History provides us several illustrations where epidemic outbreaks have led to biological disasters. Accidental or deliberate release of harmful micro-organisms can also lead to biological disasters. With the advent of bio-terrorism, there is a growing realisation that biological agents can also be used as weapons of mass destruction. The spread of Spanish Influenza of 1917-18, the Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS), Severe Acute Respiratory Syndrome (SARS), Swine Flu (H1N1), Avian Influenza (H5N1), Middle East Respiratory Syndrome (MERS), dengue, chikunguniya, Ebola o...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
Conclusions: By referring to the previous studies, we suggest that proteins including FAN, CPSF2, AGO1, AGO2, PAX5, STAT1 and PDGFB can be used as therapeutic targets of IAV infection.J Mol Microbiol Biotechnol 2015;25:311-319
Source: Journal of Molecular Microbiology and Biotechnology - Category: Microbiology Source Type: research
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