FDA Warns of Contamination Risk for Some Baclofen API LotsFDA Warns of Contamination Risk for Some Baclofen API Lots
Certain lots of baclofen active pharmaceutical ingredient (API) may be at risk for contamination with particulates and should not be used to compound sterile injectable drugs, the FDA warns. News Alerts
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Pediatric Anesthesia Informed Consent: "That's the Signpost Up Ahead - Your Next Stop, The Twilight Zone!" Anesth Analg. 2018 Dec;127(6):1289-1291 Authors: Lauro HV PMID: 30433919 [PubMed - in process]
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Publication date: Available online 16 November 2018Source: Seminars in Cancer BiologyAuthor(s): Besa Xhabija, Benjamin L. KidderAbstractEpigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types. In cancer cells, KDM5B regulates e...
Publication date: Available online 16 November 2018Source: Cancer GeneticsAuthor(s): Jennelle C. Hodge, David Bosler, Lauren Rubinstein, Navid Sadri, Shashirekha ShettyAbstractThe inv(3)(q21q26.2) altering a single chromosome 3 homolog is an established myeloid malignancy-associated entity. Comparatively, double inv(3) cases involving both homologs are exceedingly rare with 13 reports across AML, CML and MDS. This scarcity was confirmed by finding only 2 new cases out of 34,898 bone marrows collected during a 55 year period at a large medical center (0.0005%). The double inv(3) was detected by karyotype and confirmed by FI...