Vigor of peristalsis during multiple rapid swallows is inversely correlated with acid exposure time in patients with NERD

Abstract BackgroundMultiple rapid swallowing (MRS) during high‐resolution manometry (HRM) is increasingly utilized as provocative test to assess esophageal peristaltic reserve. The aim of this study was to evaluate the correlation between MRS response and impedance and pH (MII‐pH) parameters in endoscopy negative heartburn (ENH) patients. MethodsWe enrolled consecutive ENH patients, who underwent HRM and MII‐pH study, with a selected MII‐pH profile: abnormal MII‐pH (pH+/MII+); normal MII‐pH (pH−/MII−). HRM was performed with 10 wet swallows (WS) and one MRS. Mean distal contractile integral (DCI) during WS and MRS were calculated. MII‐pH parameters including acid exposure time (AET), reflux events, baseline impedance levels (BI) and the efficacy of chemical clearance evaluated with the postreflux swallow‐induced peristaltic wave (PSPW) index were measured. Key ResultsWe analyzed 103 patients: 49 MII+/pH+ (27 male), and 54 MII−/pH− (19 male). Mean age was similar between the two groups. As expected, mean AET and number of refluxes were higher in pH+/MII+ (p
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: Original Article Source Type: research

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Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Scientists at Northwestern University in Illinois studied 166 indoor dust samples and found that bacteria living within them were able to share antibiotic resistant genes with each other.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Conclusion: Although AIG is rare in children, pediatric gastroenterologists and pathologists should have a heightened suspicion for this entity in those patients with a history of autoimmune disorders and/or pernicious anemia.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research
Conclusions: Overall, gastrostomy placement was not associated with an increase in acid exposure on 24-hour multichannel intraluminal impedance pH monitoring. Similarly, the prevalence of gastro-oesophageal reflux-related symptoms did not change after gastrostomy.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research
ConclusionAccording to the notable anti-inflammatory effect in vitro and its joint protective effects on a septic mouse model, SESLA might act as an adjuvant drug candidate for sepsis, even those caused by antibiotic-resistant bacteria, e.g., CRKP.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Gastroesophageal Reflux Intervention:   Procedure: Laparoscopic sleeve gastrectomy Sponsor:   Chinese University of Hong Kong Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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