Scientists learn how poxviruses defeat the body's host defense

(University of Texas Health Science Center at San Antonio) Research shows how smallpox, a feared bioterrorism agent, and other poxviruses overcome the defenses of their hosts. Implications extend to cancer therapy, said a senior author of the work, conducted at the University of Texas Health Science Center at San Antonio.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Oncolytic viruses have a great potential to provide clinical improvement for cancer patients who do not respond to conventional therapies. The mechanisms of action include direct infection, immune-mediated cell death, and vascular collapse. We previously reported that a miRNA-regulated, thymidine kinase-deleted vaccinia virus (MDVV) specifically infects multiple myeloma (MM) cells and showed that the intravenous injection of MDVV significantly prolonged survival of severe combined immunodeficiency mice harboring a subcutaneous human RPMI8226 MM tumor (Blood 2014:124:2082, Mol Ther Oncolytics 2017;6:57). Although it was hig...
Source: Blood - Category: Hematology Authors: Tags: 801. Gene Therapy and Transfer Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionSince 2016, we have seen increasing attempts to distort or ignore medical science, clinical and epidemiological research findings to support the political ideology of the ruling party and the religious beliefs of their extreme fundamentalist supporters.  As we have discussed, most recentlyhere, the Trump regime has seen fit to put ill-informed people in positions of power in health care and public health agencies.  Some of these people have put their political and/or religious agendas ahead of the public's health.  Our examples above show a continuing inclination by the administration, its sympathi...
Source: Health Care Renewal - Category: Health Management Tags: DHHS disinformation Donald Trump ill-informed management mission-hostile management propaganda Source Type: blogs
ConclusionThis review presents an overview of the vaccinia virus from its mechanisms to medical researches and clinical trials. We believe that the solution to these problems will contribute to understanding mechanisms of VACV and provide a theoretical basis for clinical treatment.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 245 Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1 What is a HeLa cell? + Reveal the funtabulous answer expand(document.getElementById('ddet769736162'));expand(document.getElementById('ddetlink769736162')) HeLa cells a...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five George Otto Gey Glanzmann's thrombasthaenia Hela cells Henrietta Lacks NEJM new england journal of medicine Sildenafil smallpox viagra Source Type: blogs
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Cancers, Vol. 10, Pages 178: p53 and the Viral Connection: Back into the Future ‡ Cancers doi: 10.3390/cancers10060178 Authors: Ronit Aloni-Grinstein Meital Charni-Natan Hilla Solomon Varda Rotter The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanes...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
FDA is cracking down on stem cell clinics that market unapproved products and don't meet good manufacturing practice requirements. On behalf of the agency, the Department of Justice filed two complaints in federal court this week seeking permanent injunctions against a Florida-based clinic and a California-based clinic.  “Cell-based regenerative medicine holds significant medical opportunity, but we’ve also seen some bad actors leverage the scientific promise of this field to peddle unapproved treatments that put patients’ health at risk. In some instances, patients have suffered serious and per...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(University of Alberta Faculty of Medicine&Dentistry) UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to advance public health measures.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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