Scientists learn how poxviruses defeat the body's host defense

(University of Texas Health Science Center at San Antonio) Research shows how smallpox, a feared bioterrorism agent, and other poxviruses overcome the defenses of their hosts. Implications extend to cancer therapy, said a senior author of the work, conducted at the University of Texas Health Science Center at San Antonio.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Cancers, Vol. 10, Pages 178: p53 and the Viral Connection: Back into the Future ‡ Cancers doi: 10.3390/cancers10060178 Authors: Ronit Aloni-Grinstein Meital Charni-Natan Hilla Solomon Varda Rotter The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanes...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
FDA is cracking down on stem cell clinics that market unapproved products and don't meet good manufacturing practice requirements. On behalf of the agency, the Department of Justice filed two complaints in federal court this week seeking permanent injunctions against a Florida-based clinic and a California-based clinic.  “Cell-based regenerative medicine holds significant medical opportunity, but we’ve also seen some bad actors leverage the scientific promise of this field to peddle unapproved treatments that put patients’ health at risk. In some instances, patients have suffered serious and per...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(University of Alberta Faculty of Medicine&Dentistry) UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to advance public health measures.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Vaccinia virus (VACV) envelope protein D8 is one of three glycosaminoglycan adhesion molecules and binds to the linear polysaccharide chondroitin sulfate (CS). D8 is also a target for neutralizing antibody responses that are elicited by the smallpox vaccine, which has enabled the first eradication of a human viral pathogen and is a useful model for studying antibody responses. However, to date, VACV epitopes targeted by human antibodies have not been characterized at atomic resolution. Here, we characterized the binding properties of several human anti-D8 antibodies and determined the crystal structures of three VACV-mAb v...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Immunology Source Type: research
Up until the first half of the twentieth century, large-scale health disasters were mostly due to natural causes (earthquakes, volcanoes, hurricanes, etc.) or infections (e.g., smallpox, influenza epidemics, cholera). But something peculiar happened as we entered the second half of the century: Health disasters due to natural causes became dwarfed by large-scale health disasters that are man-made. Here’s a list of the Six Worst U.S. Health Disasters of the Last 50 Years, mostly man-made phenomena that have exacted huge tolls: widespread disease, premature death, poorly managed (though nonetheless highly profitable fo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gluten grain-free grains Inflammation low-carb Weight Loss Source Type: blogs
In this study, we constructed an attenuated Tian Tan strain of Guang9 with a disrupted thymidine kinase gene to enhance tumor selectivity and an inserted firefly luciferase to monitor the viral distribution by in vivo bioluminescence imaging. Living animal imaging confirmed the high specificity of vaccinia Guang9 for tumor targeting after intratumoral and intraperitoneal administration. In addition, the vaccinia Guang9 strain produced higher in vivo luciferase activity and endured longer in immunocompromised nude mice than in immunocompetent C57BL/6 mice, all of which had been tumor-challenged. The luciferase activity and ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include the Longevity Fund, first out of the gate some years ago, as well as Juvenescence and the Methuselah Fund, created this year, and a repurposing of existing funds, such as Michael Greve's Kizoo ventures. Apollo Ventures is the source of the Geroscience online magazine that helps to advance and explain the position taken on aging by this group; this is something that more investors should d...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
(Publicase Comunica ç ã o Cient í fica) For centuries, researchers assumed that the active ingredient in the vaccine providing immunity against smallpox was the cowpox virus but a study just published in the New England Journal of Medicine indicates otherwise.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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