Yersinia versus host immunity: how a pathogen evades or triggers a protective response.

Yersinia versus host immunity: how a pathogen evades or triggers a protective response.
Curr Opin Microbiol. 2015 Nov 26;29:56-62
Authors: Chung LK, Bliska JB
Abstract
The human pathogenic Yersinia species cause diseases that represent a significant source of morbidity and mortality. Despite this, specific mechanisms underlying Yersinia pathogenesis and protective host responses remain poorly understood. Recent studies have shown that Yersinia disrupt cell death pathways, perturb inflammatory processes and exploit immune cells to promote disease. The ensuing host responses following Yersinia infection include coordination of innate and adaptive immune responses in an attempt to control bacterial replication. Here, we highlight current advances in our understanding of the interactions between the pathogenic yersiniae and host cells, as well as the protective host responses mobilized to counteract these pathogens. Together, these studies enhance our understanding of Yersinia pathogenesis and highlight the ongoing battle between host and microbe.
PMID: 26638030 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - November 26, 2015 Category: Microbiology Authors: Chung LK, Bliska JB Tags: Curr Opin Microbiol Source Type: research