Paradoxical anti-TNF-associated TB worsening: Frequency and factors associated with IRIS

Conclusion After stopping biotherapy, paradoxical anti-TNF-associated TB worsening occurred most often in patients with disseminated TB. Although diagnosis remains difficult, physicians must be aware of IRIS because prolonged anti-TB treatment is not needed but, paradoxically, immunosuppressant reintroduction may be.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research