Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections

Conclusions
UFAs, IL-1β and IL-8 are elevated in NCs. However, UFAs generated via peripancreatic fat lipolysis causes worse inflammation and MSOF, converting mild AP to SAP.

Source: Gut - December 8, 2015 Category: Gastroenterology Authors: Noel, P., Patel, K., Durgampudi, C., Trivedi, R. N., de Oliveira, C., Crowell, M. D., Pannala, R., Lee, K., Brand, R., Chennat, J., Slivka, A., Papachristou, G. I., Khalid, A., Whitcomb, D. C., DeLany, J. P., Cline, R. A., Acharya, C., Jaligama, D., Murad Tags: Pancreas and biliary tract, Pancreatitis Source Type: research