Autism Spectrum Disorder Linked To PCOS In Eye-Opening New Study

Women who suffer from polycystic ovary syndrome, or PCOS, are 59 percent more likely to give birth to a child with autism spectrum disorder than women without the disorder, according to a study published in the journal Molecular Biology in December.  PCOS is a hormonal disorder that affects as many as 1 in 10 women and is the leading cause of infertility. The disorder, caused by cysts in the ovaries, is marked by abnormally high levels of the male hormone androgen, which can lead to acne, excessive hair growth, weight gain and ovulation problems. While all women produce androgens, women with PCOS overproduce them and this may account for the difference, according to the study's lead researcher. "Women with PCOS have increased levels of androgens in their bodies compared to women without PCOS, even during pregnancy,"  Kyriaki Kosidou, a psychiatrist and researcher at Karolinska Institutet in Stockholm and lead author of the study, told The Huffington Post. Those androgens could subtly influence the fetus's developing brain and nervous system, Kosidou said. The risk was even higher among women with PCOS who were also obese, perhaps because overweight women with PCOS tend to have even higher androgen levels than average-weight women with the disorder. Although ASD is five times more common in boys than in girls, according to the National Institutes of Health, babies born to mothers with PCOS in the study had the same risk, regardless of th...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

Related Links:

Date: Friday, 11 16, 2018; Speaker: Dr. Anne Steiner, Professor and Chief, Division of Reproductive Endocrinology and Infertility (REI, Duke University; Building: Building 10 (Clinical Center); FAES 6&7
Source: NIH Calendar of Events - Category: American Health Source Type: events
Authors: Hu H, Yuan G, Wang X, Sun J, Gao Z, Zhou T, Yin W, Cai R, Ye X, Wang Z Abstract Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated the effect of lifestyle intervention on ANGPTL8 concentrations. 384 obese/overweight adults with newly diagnosed T2D were randomly assigned (1:1:1) to diet (n = 128), diet + activity (n = 128) or usual care (contro...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
We report that de novo mutations in MAST1 cause mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (MCC-CH-CM) in the absence of megalencephaly. We show that MAST1 is a microtubule-associated protein that is predominantly expressed in post-mitotic neurons and is present in both dendritic and axonal compartments. We further show that Mast1 null animals are phenotypically normal, whereas the deletion of a single amino acid (L278del) recapitulates the distinct neurological phenotype observed in patients. In animals harboring Mast1 microdeletions, we find that the PI3K/AKT3/mTOR pathway is unpe...
Source: Neuron - Category: Neuroscience Source Type: research
CONCLUSIONS: The severity of NAFLD is associated with the risk of urolithiasis among NAFLD patients. Moreover, a three-variable model (obesity, APRI score, serum uric acid) could serve as a useful tool for identifying individuals at high risk for urolithiasis in patients with NAFLD. PMID: 30430908 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
People with the greatest need for weight-loss surgery -- the standard of care for severe obesity -- may have the least access and opportunity to receive treatment, a new study suggests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Eder Orlando M éndez-Salazar, María Guadalupe Ortiz-López, María de los Ángeles Granados-Silvestre, Berenice Palacios-González, Marta Menjivar
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Being statistically obese, but not simply overweight, was tied to a 27 percent increase in the odds of dying within the study period, according to new research from Boston University.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Power-frequency magnetic fields at 50 Hz do not affect fertility and development in rats and mice. Electromagn Biol Med. 2018 Nov 14;:1-12 Authors: Ruan G, Liu X, Zhang Y, Wan B, Zhang J, Lai J, He M, Chen C Abstract In the present study, the effects of power-frequency magnetic fields (PF-MF) on fertility and development were investigated in rats and mice. Adult Sprague-Dawley rats and C57BL/6J mice were divided into four groups: a sham exposure group and 30-µT, 100-µT and 500-µT PF-MF exposure groups. The rats were exposed for 24 weeks, and the exposure time for mice ranged...
Source: Electromagnetic Biology and Medicine - Category: Physics Tags: Electromagn Biol Med Source Type: research
In this study, the effects of copy numbers of lycopene synthesis genes, a variety of key central metabolic genes (especially AMP deaminase-encoding gene AMPD), and 5-L fermenter cultivation on lycopene production in Y. lipolytica were investigated and the engineered strains with significantly enhanced lycopene content (46-60 mg/g DCW) were achieved. It is therefore possible to make use of the obtained strains to meet the industrial demand of lycopene production on the basis of further genetic and process optimization.
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 16 November 2018Source: Molecular Aspects of MedicineAuthor(s): Joseph M. Pappachan, Cornelius J. Fernandez, Elias C. ChackoAbstractThe prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their ...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
More News: Acne | Autism | Babies | Biology | Boys | Brain | Children | Eating Disorders & Weight Management | Girls | Health | Hormones | Infertility | Molecular Biology | National Institutes of Health (NIH) | Neurology | Obesity | Ovaries | Polycystic Ovary Syndrome | Pregnancy | Psychiatry | Reproduction Medicine | Study | Websites | Women