Infertility in Men Tied to Heart Disease, Chronic Conditions Infertility in Men Tied to Heart Disease, Chronic Conditions
Compared with men with vasectomies or receiving fertility tests, those with infertility had increased risks for heart disease, diabetes, substance abuse, liver disease, and renal disease. Medscape Medical News
In this study, JMJD3 was identified unexpectedly as a gene-specific transcriptional partner of SIRT1 and epigenetically activated mitochondrial β-oxidation, but not gluconeogenic, genes during fasting. Mechanistically, JMJD3, together with SIRT1 and the nuclear receptor PPARα, formed a positive autoregulatory loop upon fasting-activated PKA signaling and epigenetically activated β-oxidation–promoting genes, including Fgf21, Cpt1a, and Mcad. Liver-specific downregulation of JMJD3 resulted in intrinsic defects in β-oxidation, which contributed to hepatosteatosis as well as glucose and insulin intol...
This study aimed to clarify functions of uterine HIF using transgenic mouse models. Mice with deletion of Hif2a in the whole uterus (Hif2a-uKO mice) showed infertility due to implantation failure. Supplementation with progesterone (P4) and leukemia inhibitory factor (LIF) restored decidual growth arrest and aberrant position of implantation sites in Hif2a-uKO mice, respectively, but did not rescue pregnancy failure. Histological analyses in Hif2a-uKO mice revealed persistence of the intact luminal epithelium, which blocked direct contact between stroma and embryo, inactivation of PI3K-AKT pathway (embryonic survival signal...
Elevated fasting blood glucose and HbA1c from one blood sample had a high positive predictive value for subsequent diabetes and other clinical endpoints.Medscape Medical News
Insulin prices have nearly tripled in a decade, putting the life-sustaining drug out of reach for some people with diabetes, and the American Medical Association is calling for more transparency.Medscape Medical News
Conclusion: NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.Kidney Blood Press Res 2018;43:987 –999
Recent-onset type 2 diabetes has been linked to pancreatic cancer in African Americans and Hispanics older than 50, according to a study.
DIABETES type 2 symptoms are not always apparent, but it ’s important to recognise all the signs or do what you can to prevent the condition as it can lead to other health problems such as heart disease and stroke. One of the ways to reduce your risk of diabetes is by eating a healthy, balanced diet. Certain drinks can make blood sugar spike, but the fo llowing five can help keep it level.
University of Southern California researchers claim being diagnosed with type 2 diabetes after the age of 50 could be a sign of pancreatic cancer as rates are higher than in long-term diabetics.
Conditions: Diabetes Mellitus, Type 2; Sarcopenia; Weight Loss; Frailty Interventions: Behavioral: Circuit resistance training (CRT); Behavioral: Vegeterranean diet (V-Med diet); Drug: Empagliflozin 10 MG Sponsor: Tel-Aviv Sourasky Medical Center Recruiting
Conditions: Heart Failure; Type 2 Diabetes Mellitus Intervention: Drug: Beta-hydroxy-butyrate Sponsor: The University of Texas Health Science Center at San Antonio Not yet recruiting