Adiponectin: an Endothelium-Derived Vasoprotective Factor?

Adiponectin: an Endothelium-Derived Vasoprotective Factor?
Curr Vasc Pharmacol. 2015 Dec 2;
Authors: Shen L, Evans IM, Souza DS, Dreifaldt M, Dashwood MR, Mohamed-Ali V
Abstract
Adipose tissue (AT) is now widely accepted as a key secretary organ, as well as an energy storage depot. It secretes a series of cytokines, hormones and bioactive molecules: adipokines. Adiponectin is an abundant systemic adipokine that uniquely is reduced in obesity and increases on weight loss, is anti-inflammatory, promotes insulin sensitivity and affords cardiometabolic protection. It was considered a true adipokine, in that it is exclusively generated by the adipocytes of the adipose tissue. However, recent evidence points to it being secreted by a range of other organs. This review summarizes the non-adipose sources of adiponectin especially that derived from the endothelium, its vasoprotective role and intracellular signalling pathways. Endothelium derived adiponectin may potentially be a new target for clinical intervention in cardiovascular disease.
PMID: 26638793 [PubMed - as supplied by publisher]

Source: Current Vascular Pharmacology - December 2, 2015 Category: Drugs & Pharmacology Authors: Shen L, Evans IM, Souza DS, Dreifaldt M, Dashwood MR, Mohamed-Ali V Tags: Curr Vasc Pharmacol Source Type: research