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Infertile men have a higher risk of heart disease, diabetes, Stanford study finds

(Stanford University Medical Center) Men diagnosed with infertility have a higher risk of developing other general health ailments, including diabetes, ischemic heart disease, alcohol abuse and drug abuse, compared with fertile men, according to a study by researchers at the Stanford University School of Medicine.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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Authors: Alanazy MH, Barakeh RB, Asiri A, Edrees MF, Abuzinadah AR, Aljafen BN, Muayqil T Abstract Only a small fraction of patients with acute ischemic stroke receive intravenous thrombolysis (IVT). We sought to assess barriers and practice patterns in using IVT for acute ischemic stroke among neurologists in Saudi Arabia. An electronic survey was sent to all neurologists registered with the Saudi Commission for Health Specialties. A total of 148 (77.5%) neurologists responded. The most common reported barriers for IVT administration were delayed presentation to hospitals (82.4%) and unclear time of symptom onset ...
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
Introduction: Necrobiosis lipoidica (NL) is an idiopathic, chronic granulomatous disease linked to diabetes mellitus (DM). We aim to identify comorbidities and complications of NL. Methods: A retrospective study was performed within Mayo Clinic from 1992 to 2017. 328 cases were identified using International Classification of Diseases (ICD) code diagnosis of NL and a clinical diagnosis of NL by a dermatologist or histopathological diagnosis consistent with NL. A chart review recorded lifestyle, comorbidities, and complications.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Epidemiological studies revealed a decreased susceptibility to develop an allergic contact dermatitis (ACD) in individuals with autoimmune diseases like type I diabetes or rheumatoid arthritis compared to healthy individuals. However, the clinical relevance of this inverse correlation has not been evaluated so far. In our study, we want to confirm these results by analyzing the induction of a contact hypersensitivity (CHS) reaction, which resembles the ACD in humans, in non-obese diabetes (NOD) mice spontaneously developing an autoimmune insulin-dependent diabetes mellitus was analysed.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
This study identified major epitopes for DPP4i-BP autoAbs using 10 sera without anti-NC16A autoAbs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease. It causes intense pruritus and blistering, which have extensive effects on patients quality of life. The incidence of BP is increasing, although it is not yet known why. In recent years, a theory has emerged that BP may be triggered by the use of dipeptidyl peptidase 4 (DPP-4) inhibitors in the treatment of diabetes. Our nationwide study was designed to investigate the association between the use of diabetes drugs (excluding insulin) and BP, by analysis of Finnish registry data for 3397 BP patients and 12941 patients with basocellular carcinoma as controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
The term “therapeutic patient education” (TPE) refers to teaching by healthcare practicioners that is designed to help patients and families manage chronic disease and improve quality of life. TPE improves treatment adherance, reduces complications, reduces overall cost of care and improves survival in c ongestive heart failure, diabetes mellitus and rheumatoid arthritis, among other diseases. Stalder et al and other groups have described implementation of TPE for atopic dermatitis (AD). Widespread implementation of TPE programs for AD has been limited by issues of cost, limited time during a clinic visit, and ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Elevated circulating levels of three pro-inflammatory cytokines (IL-1 β IL-6 and TNFα) are linked to the development of multiple, age-associated chronic disorders in aged humans (arthrosclerosis, diabetes, and Alzheimers disease. While regimens that reduce levels of circulating cytokines are not yet available, our recent studies in aged mice demonstrate that 1) age- associated epidermal dysfunction stimulates cutaneous pro-inflammatory cytokine production, accounting elevations in circulating cytokine levels, independent of liver or T-cell contributions; and 2) approaches that improve epidermal function reduce n...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research
In this study, we seek to determine: (i) the pathogenic role of psoriasis-signature cytokines in the development of adipocyte-related disorders, and (ii) the role of adipose tissue-derived mediators in triggering and/or amplifying skin inflammation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
Psoriasis is IL-23/type17 T cell axis inflammation and known to be associated with diabetes. Although causal relationship between psoriasis and diabetes has been proposed based on the clinical study, it has not been reported if successful treatment of psoriasis affect the status of diabetes. Here we showed that severe psoriatic patients (PASI20) had higher blood glucose level than less severe psoriatic patients (PASI
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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