Molecular processes for targeted dog cancer therapy investigated

Dogs get cancer, just like humans. Scientists are now exploring the molecular basis of cancer progression in canine cell lines. Modern cancer therapy has been revolutionized with the introduction of new drugs, so-called ‘targeted drugs’, but the basis for the application of these new agents in cancer therapy is a deep understanding of the molecular mechanisms of the disease, even with pets. Now a research team has investigated the activation of genetic regulatory mechanisms in canine cells and found both matches as well as differences compared to humans.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt, Marc A. G. G. Vooijs
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
(Charit é - Universit ä tsmedizin Berlin) The doctoral program 'CompCancer - Computational Methods in Oncology: Towards Personalized Medicine in Cancer Therapies' has received approval from the German Research Foundation (DFG). As part of this research program, a new generation of researchers will be developing computer-based tools for use in cancer research. The new Research Training Group is headed by Prof. Dr. Nils Bl ü thgen of Charit é - Universit ä tsmedizin Berlin.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In conclusion, our findings provide a novel biological basis to support the current successful strategy using combined VEGF/PD ‐1 signalling blockade in cancer therapy.
Source: Journal of Cellular and Molecular Medicine - Category: Molecular Biology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Aryl hydrocarbon receptor ligand 5F 203 induces the expression of putative tumor suppressor cytoglobin (CYGB) and promotes anticancer activity and apoptosis in vivo and in vitro. CYGB promotes 5F 203 –mediated cell death, caspase‐3/‐7 activation, proapoptotic gene expression, lysosomal membrane permeabilization (LMP), and cathepsin B release in triple negative breast cancer (TNBC) cells. These findings suggest that AhR ligands such as 5F 203 upregulate CYGB to confer TNBC cell death. AbstractNearly 40 000 women die annually from breast cancer in the United States. Clinically available targeted breast cancer thera...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Jan Skoda, Karolina Borankova, Patric J. Jansson, Michael L.-H. Huang, Renata Veselska, Des R. RichardsonAbstractMitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate....
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Authors: Di C, Zhang Q, Wang Y, Wang F, Chen Y, Gan L, Zhou R, Sun C, Li H, Zhang X, Yang H, Zhang H Abstract Exosomes are nanoscale vesicles shed from all cell types and play a major role in communication and transportation of materials between cells due to their ability to transfer proteins and nucleic acids from one cell to another. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Exosomes can also induce chemoresistance or radioresistance of tumor cells. Studies about the related m...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Abstract Manipulating the assembly of gold nanoparticles (AuNPs) for maximizing the photothermal effect is a promising strategy for cancer therapy. Herein, taking advantage of the well-known tetrazole/alkene photo-click chemistry, we for the first time demonstrated that small AuNPs (23 nm) decorated with both 2, 5-diphenyltetrazole and methacrylic acid on the surface could form covalently cross-linked aggregates upon laser irradiation (λ = 405 nm). The in vitro studies indicated that the light-triggered assembling remarkably shifted the surface plasmon resonance of AuNPs to near-infrared (NIR) regions, whic...
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
iś B Abstract Telomerase is perceived as an immortality enzyme that enables passing the Hayflick limit. Its main function is telomere restoration but only in a limited group of cells, including cancer cells. Since it is found in a vast majority of cancer cells, it became a natural target for cancer therapy. However, it has much more functions than just altering the metabolism of telomeres-it also reveals numerous so-called non-canonical functions. Thus, a question arises whether it is always beneficial to turn it off when planning a cancer strategy and considering potential side effects? The purpose of this revie...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Publication date: Available online 15 November 2018Source: Saudi Journal of Biological SciencesAuthor(s): Yong Cao, Fei Dai, Yanmei Li, Lu Jia, Yunpeng Luan, Youjie ZhaoAbstractThe roots of Codonopis bulleynana Forest ex diels (cbFed), locally known as Tsoong, have been used as a tonic food. Tsoong has wide range of pharmacological effects, including anticancer effects. In the present study, the anticancer activity of Tsoong and its potential molecular mechanisms were investigated. Using high throughput sequencing the apoptotic pathway was ranked as one of the most important pathways and the differential expressions of apo...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 16 November 2018Source: Nano TodayAuthor(s): Homan Kang, Shuang Hu, Mi Hyeon Cho, Suk Ho Hong, Yongdoo Choi, Hak Soo ChoiAbstractNanomaterials have revolutionized cancer imaging, diagnosis, and treatment. Multifunctional nanoparticles in particular have been designed for targeted cancer therapy by modulating their physicochemical properties to be delivered to the target and activated by internal and/or external stimuli. This review will focus on the fundamental “chemical” design considerations of stimuli-responsive nanosystems to achieve favorable tumor targeting beyond biolog...
Source: Nano Today - Category: Nanotechnology Source Type: research
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