Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus.

Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus. Acta Derm Venereol. 2015 Dec 3; Authors: de Carvalho GC, Domingues R, Almeida de Sousa Nogueira M, Calvielli Castelo Branco AC, Gomes Manfrere KC, Vieira Pereira N, Aoki V, Nacagami Sotto M, Da Silva Duarte AJ, Notomi Sato M Abstract Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 expression were measured in the skin lesions and sera of subjects with LP. S100A8 expression induced a greater cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Increased expression of interleukin (IL)-1β, tumour necrosis factor (TNF) and IL-6 in the CD8+ T cells of patients with LP was induced by S100A8, in contrast to IL-10 and interferon (IFN) type I genes in the control group. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions. PMID: 26632637 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research