Leading Drug For Type 2 Diabetes May Hold Key To Longer Living

BOSTON (CBS) — Metformin is a pill used by millions of Americans with type 2 diabetes to control high blood sugar.  It is also sometimes used in women with polycystic ovary syndrome and infertility. Now researchers are looking at metformin as a possible anti-aging drug.  That’s because studies have shown that the drug may improve the health and lifespan of certain types of worms and mice. The FDA has given the green light for researchers to conduct the first clinical trials in humans with 3,000 older adults to see if the drug can slow the progression of certain age-related conditions and even improve survival. In 2012, the average life expectancy in the United States was 78.8 years. Some experts wonder if a drug like metformin could extend human life to 120 years or beyond.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local CBS Boston WBZ Source Type: news

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CONCLUSION: In addition to pharmacological interventions, long-term standardized individualized management of PCOS patients is needed to achieve fertility and reduce the risk of metabolic related diseases. PMID: 30706800 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with poor reproductive outcomes, including infertility and pregnancy complications, and poor metabolic outcomes, including insulin resistance, type 2 diabetes, and the metabolic syndrome. Prevalence estimates for PCOS range from 7% to 15% of reproductive-age women worldwide, depending on the diagnostic criteria used. Accordingly, PCOS-associated dysglycemia and obesity are a global public health risk. Despite the public health importance of PCOS, notable gaps exist in the literature regarding its pathophysiology, natural history, and optimal management.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Polycystic ovary syndrome (PCOS) is a complex endocrine condition that represents a lifelong health concern for 1 in 10 women worldwide.1 PCOS is commonly diagnosed by the presence of ovulatory dysfunction, androgen excess, and/or ovaries with polycystic morphology on ultrasound examination.2 Half of patients experience overweight or obesity.3 Most are at increased risk for serious comorbidities, including infertility, pregnancy complications (eg, gestational diabetes mellitus), impaired glucose tolerance, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, gynecological cancers, anxiety, depression, eati...
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Research Source Type: research
It continues to happen: I run into people who say to me “I follow the Wheat Belly lifestyle. I eat gluten-free!” When I ask them what that means, they tell me that they only eat gluten-free bread, pasta, pizza, cookies, etc. I’m not entirely sure why this misinterpretation of the Wheat Belly message is so common. Let’s talk about this important distinction, as being gluten-free can be an absolute health and weight disaster, unlike the magnificent health and weight loss we enjoy on the Wheat Belly lifestyle when done right. It’s perfectly fine to be gluten-free, i.e., avoiding wheat, rye, and b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune blood sugar gluten gluten-free grain grain-free grains Weight Loss wheat belly Source Type: blogs
Conclusions: Loss-of-function mutations of DLK1 are a definitive cause of familial CPP. The high prevalence of metabolic alterations in adult women who experienced CPP due to DLK1 defects suggests that this antiadipogenic factor represents a novel link between reproduction and metabolism. PMID: 30462238 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Most mainstream doctors believe that polycystic ovary syndrome, PCOS, is a disease. PCOS is, after all, associated with markedly increased risk for type 2 diabetes, hypertension, endometrial cancer, and heart disease, in addition to outward signs that include excessive facial and body hair, tendency to being overweight or obese, irregular menstrual cycles, infertility. A crisis of self esteem commonly and understandably results. Mainstream doctors tell you to not worry because they have plenty of prescription drugs to “treat” it, not to mention various hormones, fertility procedures, and gastric bypass. PCOS is...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates acne facial change facial hair gluten-free grain-free grains Inflammation pcos polycystic ovary testosterone undoctored Weight Loss wheat belly Source Type: blogs
Publication date: May 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 12, Issue 3Author(s): Muhammad Bilal, Abdul Haseeb, Abdur RehmanAbstractBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. The two main documented pathogenic mechanisms are hyperinsulinemia and hyperandrogenemia but there is growing evidence for increased predisposition to cardiovascular disease, dyslipidemia, and type 2 diabetes mellitus. Our study aims to analyze the association of PCOS with cardiovascular risk factors.MethodsThis is a prospective st...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSIONS: Primary infertility, T2DM familial history, hypertriglyceridemia, low cholesterol-HDL, older age, waist circumference> 80 cm, and high LH may confer poorer fertility treatment results. PMID: 29944229 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
BOSTON (CBS) – Researchers from the University of Oregon studied six women with polycystic ovary syndrome (PCOS) and found that when they soaked in a hot tub for one hour three to four times a week they experienced a variety of health benefits. After two months, the women had reduced resistance to insulin, lower blood pressure and heart rate and some even had more regular menstrual cycles and clearer skin. PCOS affects about 10% of women of reproductive age. It causes multiple cysts to form on the ovaries and also increases a woman’s risk of obesity, type 2 diabetes, and infertility. The researchers say the hot...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Watch Listen Dr. Mallika Marshall Source Type: news
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in adult women (1). It can't be cured, but thanks to many years of fruitful research and intensive investigation, multiple modalities to help manage the condition throughout a woman's lifetime have emerged. Those of us who have been in practice for more than a decade or two have likely had the experience of managing mothers and daughters with the condition. Many of us have supported our PCOS patients through an adolescence complicated by acne and hair growth, an early adulthood complicated by infertility and irregular menses, and late reproductive age compl...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
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