This Month in

Genome-wide association studies (GWASs) have produced vast numbers of SNPs associated with various traits; however, the nature of many of these signals remains unclear. Determining the true functional variants underlying the signal and the consequences of variation at these sites requires experimental validation of each of these GWAS loci. In this issue, Roman et al. fine mapped a region near GALNT2, a gene whose protein product is involved in high-density lipoprotein cholesterol (HDL-C) metabolism and associated with blood lipid and cholesterol levels.

Source: The American Journal of Human Genetics - December 3, 2015 Category: Genetics & Stem Cells Authors: Sarah Ratzel, Sara B. Cullinan Tags: Editors’ Corner Source Type: research