LIBERATE Patients from Emphysema!

PITTSBURGH. (Ivanhoe Newswire) -- More than four million Americans have emphysema, a chronic lung disease that makes it impossible to take a full breath. Major surgery to remove the damaged part of the lung or a lung transplant used to be the best options for some patients with advanced cases. Now, doctors at 17 sites nationwide are testing a minimally- invasive procedure that may save lives.
Source: Medical Headlines From - Category: Consumer Health News Source Type: news

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α1-antitrypsin (AAT) is an acute phase protein, major inhibitor of neutrophil proteases and considered as a regulatory protein of broad immune and inflammatory responses. Inherited AAT deficiency predisposes to an early-onset pulmonary emphysema and pneumothorax, and is a common indication for lung transplantation. Both preclinical and clinical experience show that therapy with plasma purified AAT is beneficial for emphysema patients with AAT deficiency but also useful for a broad spectrum of inflammatory and immune-mediated diseases.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 363 Source Type: research
Although lung transplantation and lung volume reduction (both surgically and endoscopically: LVRS/ELVR) are well established therapies for end-stage emphysema patients, data on LVR prior to LuTX remains scarce. Thus, we aim to analyze the impact of pre-transplant LVR on post-LuTX outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 829 Source Type: research
Irisin is a skeletal muscle cell-derived myokine associated with physical activity. Recently, decreased serum irisin levels have been shown to cause alveolar epithelial apoptosis resulting in lung emphysema in patients with chronic obstructive pulmonary disease. Similar to the patients with emphysema, the patients with chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT) could show emphysematous changes, because in LDLLT, small lobar grafts expand to fit into the recipient's chest cavity due to the size mismatch.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1026 Source Type: research
an MK Abstract RATIONALE: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality. OBJECTIVES: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. METHODS: Resected lungs were inflated, frozen, and systematically sampled, generating 33 COPD (n=11 su...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
CONCLUSION: The twenty-five years experience shows a consistent improvement in the results of lung transplantation which is now accepted as the only effective curative treatment for end stage lung disease. PMID: 30686555 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Poggi C, Mantovani S, Pecoraro Y, Carillo C, Bassi M, D'Andrilli A, Anile M, Rendina EA, Venuta F, Diso D Abstract Chronic obstructive pulmonary disease (COPD) is the major causes of disability and mortality. The efficacy of maximal medical treatment, although effective at the early stages of the disease, becomes limited when extensive alveolar destruction is the main cause of respiratory failure. At this stage of the disease more aggressive options, when feasible, should be considered. Lung transplantation and lung volume reduction surgery (LVRS) are currently available for a selected group of patients. E...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Abstract COPD-associated chronic inflammation has been shown to lead to an autoimmune phenotype characterized in part by the presence of lung reactive autoreactive antibodies. We hypothesized that ischemia reperfusion injury (IRI) liberates epitopes that would facilitate pre-existing autoantibody binding, thereby exacerbating lung injury post-transplantation. We induced emphysema in C57BL/6 mice through 6 months of cigarette smoke exposure (CS). CS exposure significantly elevated serum autoantibodies compared to non-smoke age-matched (NS) mice. To determine the impact of a full pre-existing autoantibody repertoire...
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
Publication date: Available online 30 November 2018Source: Seminars in Ultrasound, CT and MRIAuthor(s): Brett M. Elicker, Kimberly G. Kallianos, Kirk D. Jones, Travis S. HenryAbstractSmoke from cigarettes and other sources may induce a variety of patterns of lung injury. While smoking related lung diseases, in general, have a better prognosis than many other diffuse lung diseases, they may be a cause of significant symptoms and, in some cases, may even require lung transplantation. On histology the manifestations of these patterns range from reversible inflammation to irreversible emphysema or fibrosis. High-resolution che...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Conclusion: CLO in adults is rare and is associated with a broad spectrum of symptoms. Precise anamnesis and radiological findings confirm the diagnosis. Surgical resection is the treatment of choice in symptomatic patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: We identified production of IL-17A among populations of ILCs, gamma delta T cells and iNKT cells in different lung disease entities which suggests that these cell populations can contribute to IL-17A-dependent pathologies in end stage lung disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
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