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LIBERATE Patients from Emphysema!

PITTSBURGH. (Ivanhoe Newswire) -- More than four million Americans have emphysema, a chronic lung disease that makes it impossible to take a full breath. Major surgery to remove the damaged part of the lung or a lung transplant used to be the best options for some patients with advanced cases. Now, doctors at 17 sites nationwide are testing a minimally- invasive procedure that may save lives.
Source: Medical Headlines From Ivanhoe.com - Category: Consumer Health News Source Type: news

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Abstract This brief imaging case report highlights a successful bridge to lung transplantation after endobronchial coil assisted lung volume reduction procedure. Our patient was a 64-year-old male with severe emphysema (FEV1:19%, RV: 289%, TLC: 143%), on maximum medical regimen who was enrolled into the Lung Volume Reduction Coil Treatment (RENEW) Study. He underwent bilateral endobronchial coil placement in a two-step procedure, with an immediate improvement in symptoms and pulmonary function testing (FEV1:21%, RV: 254%, TLC: 138%). The need for lung transplantation was delayed by three and half years because of ...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Circulating tumor DNA (ctDNA) analysis has demonstrated excellent specificity and satisfactory sensitivity to detect somatic mutations across many tumor types and particularly in patients with metastatic disease [1,2]. ctDNA detection rate and level primarily depend on tumor burden, proliferation and tumor type [3]. Its clinical use as a theragnostic biomarker for detectingEGFR mutation has been approved in stage IV non-small-cell lung cancer patients, in whom invasive tumor biopsy may be perilous because of limited accessibility and/or pre-existing organ dysfunction (e.g. emphysema). In that regard, biopsies of hepatocell...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Increasing evidence indicates a role for recipient autoimmunity in the pathogenesis of graft rejection. COPD, which accounts for over 25% of all lung transplants (LTx), is caused by chronic inflammation, which has been shown to lead to an autoimmune phenotype characterized by the production of extracellular matrix (ECM) autoreactive antibodies (aAbs). Here we investigated the impact of recipient pre-existing aAbs on early post-transplant (Tx) outcomes. We hypothesize that ischemia reperfusion injury (IRI) liberates ECM epitopes and facilitate aAb binding, leading to lung injury.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Immune-modifying processes such as IPF and COPD result in a recipient environment that can be hostile to allografts by, as of yet, ill-defined mechanisms. In an era driving towards personalized medicine, a better understanding of the potentially differing immune mechanisms in different populations may identify novel therapeutic approaches to improve outcomes. Here we utilize a systems biology approach to determine the impact of recipient pre-transplant emphysema on post transplant graft survival.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
CONCLUSIONS: Cela1 is important in physiologic and pathologic stretch-dependent remodeling processes in the postnatal lung. AAT is an important regulator of this process. Our findings provide proof-of-concept for the development of anti-Cela1 therapies to prevent and/or treat AAT-deficient emphysema. PMID: 29420065 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 75-year-old man is seen for routine follow-up for very severe COPD. He has constant dyspnea and air hunger and spends most of the day in a chair. He has had no change in baseline cough and sputum production. He has had multiple COPD exacerbations that required ICU admission and intubation. He has not benefited from pulmonary rehabilitation in the past. He quit smoking 3 years ago. His medical history is also notable for hypertension, type 2 diabetes mellitus, and a myocardial infarction 3 years ago. Hi...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Palliative Care Pulmonology Source Type: blogs
Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressure (PAP) greater or equal to 25 mmHg, and is a frequent complication in patients with idiopathic pulmonary fibrosis (IPF) [1], especially at an advanced stage of the disease, or when emphysema is associated, as in the syndrome of combined pulmonary fibrosis and emphysema [2]. At diagnosis, 8% to 15% of patients with IPF may already have precapillary PH [3], a proportion which rises up to 30% to 50% of patients at the time of evaluation for lung transplantation [4–7]. The frequency of PH further increases with comorbidities such as obstructiv...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease, Pulmonary vascular disease Editorials Source Type: research
Authors: Kahn N, Andrianopoulos V, Mekov E, Herth FJF Abstract This review highlights a selection of abstracts from the 2017 ERS International Congress in Milan presented by the clinical assembly's groups of interventional pulmonology, general practice and primary care and rehabilitation and chronic care. Attention is brought to the increasing burden of disease of COPD and end-stage emphysema patients in China. The considerable efforts of Chinese pulmonary centers to conduct multicenter, randomized and controlled trials, investigating the possibilities of bronchoscopic lung volume reduction is underlined in the rev...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
We report here the case of a woman who underwent bilateral lung transplantation for severe emphysema. On day 25 after transplantation, endobronchial greenā€black lesions were detected during routine endoscopy. Endobronchial swabs, biopsies, and bronchoalveolar lavage samples were positive for Microascus cirrosus. This fungal infection developed despite voriconazole given for previous persistent invasive aspergillosis. Treatment consisted of a combination of antifungal medication (voriconazole, terbinafine, amphotericin B, and caspofungin) and endoscopic resection of necrosed bronchial mucosa. A favorable clinical outcome ...
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: CASE REPORT Source Type: research
Rationale: Patients with severe COPD and/or emphysema have a distinct pulmonary inflammome characterized by a different regulation of the immune response that should be better explored integrating the results of RNA expression with epigenetic changes.Objective: To compare the pulmonary mRNA and miRNA of COPD patients with and without emphysema (CT scan) and various disease severity.Methods: Lung tissue from 70 former smokers with COPD was obtained from individuals undergoing thoracic resectional surgery (mostly because of lung cancer) or lung transplantation explants. Total RNA was extracted, small RNA libraries were const...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular Pathology and Functional Genomics Source Type: research
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