ALung’s artificial lung tech selected for landmark pivotal trial

ALung Technologies said today its Hemolung RAS extracorporeal carbon dioxide removal device has been selected for use in the world’s 1st pivotal trial of ECCO2R technology used to treat patients with acute respiratory failure. The U.K.’s National Institute for Health Research will supply $3.1 million (GBP £2.1 million) in funding for the 1,120 patient Rest trial, which looks to examine the effect of protective ventilation with veno-venous lung assist devices during respiratory failure. The trial will be jointly led by Queen’s University and Belfast Health and Social Services Trust, the company said. “Reducing ventilator pressures has been one of the most important interventions shown to improve outcomes in these critically ill patients. Use of these lung-protective ventilation strategies, however, leads to a critical accumulation of carbon dioxide in the blood. Carbon dioxide can be removed from the blood independently of the failing lungs with an extracorporeal device in a manner similar to kidney dialysis, thus enabling implementation of safer mechanical ventilation settings. We have shown through several pilot studies that the Hemolung RAS can safely and effectively meet this clinical need, and are very excited to embark on this pivotal study to determine the impact of this strategy on patient outcomes,” clinical and scientific affairs veep Laura Lund said in a press release. ALung will provide its Hemolung systems and treatment kits to ...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Clinical Trials Respiratory ALung Technologies Inc. Source Type: news

Related Links:

Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chan Feng1, Donglei Zhu1, Lv Chen1, Yonglin Lu1, Jie Liu1, Na Yoon Kim2, Shujing Liang1, Xia Zhang1, Yun Lin1, Yabin Ma3* and Chunyan Dong1* 1Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China 2Department of Chemical Engineering, Northeastern University, Boston, MA, United States 3Pharmacy Department, Shanghai East Hospital, Tongji University, Shanghai, China The off-target activation of photosensitizers is one of the most well-known obstacles to effective photodynamic therapy (PDT). The selected activation of photosensitizers in cancer cells is highly desired to overcome this problem. We...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We describe the ethical framework, logistical challenges, and rationale for the current single center (NCT03101891) and planned multicenter trial.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
In the setting of Cardiogenic Shock (CS), impaired biventricular function can lead to an acute decrease in renal function via reduced renal perfusion and increased renal venous pressure. In a nationally representative sample, we sought to analyze the characteristics and outcomes of patients hospitalized with CS requiring renal replacement therapy (hemodialysis) for acute kidney injury (AKI-HD).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 132 Source Type: research
To analyze post-heart transplantation (HTx) outcomes in selected patients on ECMO support. Our local strategy is to transplant ECMO-patients without mechanical ventilation or kidney failure (creatinine clearance ≤ 30 mL/min or dialysis). In addition, specific pre-transplant (intra-aortic balloon pump, reperfusion canula) and post-transplant strategies (maintaining ECMO after HTx) were applied.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 251 Source Type: research
This study analysed its impact on the mortality and long-term renal function in adult cardiac recipients in the UK.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 332 Source Type: research
Although renal function may improve after left ventricular assist devices (LVAD) implantation, acute kidney injury (AKI) requiring hemodialysis (HD) therapy can occur post-operatively. We sought to investigate in-hospital outcomes and readmissions among patients who developed AKI requiring HD during index admission for LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 872 Source Type: research
This study aimed to examine its impact on the mortality and long-term renal function in the adult lung recipients in the UK.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1043 Source Type: research
If you've ever known someone who has had to be on dialysis, you know that the quality of life for dialysis patients is not great. First of all, there is a pill burden. "My patients need to eat 20 to 30 pills a day," Victor Gura, MD, an internist, nephrologist, and inventor of the Wearable Artificial Kidney (WAK) told MD&M West attendees on Tuesday. "So one was making a joke. He said 'I could put them in a bowl with some dressing and have a salad'. The bottom line is it's a burden and it's also expensive." In addition to the pill burden, dialysis patients are restricted in the amo...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Design Source Type: news
We learn from basic physiology  lessons that human body is made up of 60 % water. What about heart ? There is no reason for the heart should behave differently from rest of the body . If my  assumptions are correct when the normal heart weighs 300g  , 180g of which should be  be water. The same thing could be applicable for LV mass( * Reference requested) Is there myocardial congestion in cardiac failure ? Genesis of edema in any tissue depends on local hydrostatic pressures, tissue resistive forces, osmotic balance, and cell membrane permeability. In the myocardium individual contri...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: cardiac failure Cardiac MRI Cardio Nephrology effect of dialysis on myocardial water content lv amss and myocardial edema myocardial edema and ckd chronic kidney failure myocardial interstitial edema myocardial water imaging water logging Source Type: blogs
More News: Clinical Trials | Dialysis | Funding | Health | Hospitals | Kidney Transplant | Lung Transplant | Medical Devices | National Institute for Health Research (NIHR) | Respiratory Medicine | Study | Urology & Nephrology