Comparative evaluation of chromID MRSA agar and Brilliance 2 MRSA agar for detection of MRSA in clinical samples.

Comparative evaluation of chromID MRSA agar and Brilliance 2 MRSA agar for detection of MRSA in clinical samples. Br J Biomed Sci. 2013;70(1):41-3 Authors: McElhinney R, Millar C, Scopes E PMID: 23617097 [PubMed - indexed for MEDLINE]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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Abstract Healthcare-associated infections (HAIs) not only bring additional medical cost to the patients but also prolong the length of stay (LOS). 2119 HAI case-patients and 2119 matched control-patients were identified in 68 hospitals in 14 primary sampling provinces of 7 major regions of China. The HAI caused an increase in stay of 10.4 days. The LOS due to HAI increased from 9.7 to 10.9 days in different levels of hospitals. There was no statistically significant difference in the increased LOS between different hospital levels. The increased LOS due to HAI in different regions was 8.2 to 12.6 days. Comparing b...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractHistorically, vancomycin has been considered a primary therapeutic option for treating infections withStaphylococcus aureus, but isolates with reduced vancomycin susceptibility (SA-RVS) (MIC  ≥ 4 μg/mL) have emerged. Telavancin, a semisynthetic lipoglycopeptide, is an alternative treatment option forS. aureus, but data examining telavancin activity against SA-RVS are limited. In the present study, we characterize 300 isolates ofS. aureus isolates (50 vancomycin-susceptible (VSSA) isolates and 250 SA-RVS isolates) from a large tertiary care, academic medical center, 51.8% of which were methi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractMethicillin-resistantStaphylococcus aureus (MRSA) is an important cause of infections in humans. Photodynamic therapy using blue light (450  nm) could possibly be used to reduce MRSA on different human tissue surfaces without killing the human cells. It could be less harmful than 300–400 nm light or common disinfectants. We applied blue light ± riboflavin (RF) to MRSA and keratinocytes, in an in vitro liquid layer model, and compar ed the effect to elimination using common disinfection fluids. MRSA dilutions (8 × 105/mL) in wells were exposed to blue light (450  nm) &...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Violet Vakunseh Bumah, Daniela Santos Masson-Meyers, Chukuka Samuel EnwemekaAbstractIn our recent study, we showed that pulsed blue light (PBL) suppresses the growth of Propionibacterium acnes more than continuous wave (CW) blue light in vitro, but it is not known that other bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), respond similarly to PBL. The high potency of PBL relative to CW blue light makes it a suitable antimicrobial for suppressing bacterial growth in biofilms as wel...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 11 November 2019Source: The Lancet Respiratory MedicineAuthor(s): Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael Lee, Sharon McNamara, Laura Nay, Marcella Blackledge, Ahmet Uluer, David M Orenstein, Michelle Mann, Wynton Hoover, Ronald L Gibson, Jane L Burns, Lucas R Hoffman, Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael LeeSummaryBackgroundStaphylococcus aureus is the bacterium cultured most often from respiratory secretions of people with cystic fibrosis. Both meticillin-susceptible S aureus and meticillin-resistant S aureus (MR...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
This study surveys the clinical relevance of the nasalStaphylococcus aureus colonization status on intensive care unit (ICU) –acquiredS.aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified through a second (negative) culture. Spa typing and virulence gene profiling were performed for all isolates. Twenty sixS.aureus infections were detected in the carriage group and 20 in the non-carriage group. Eighteen of these ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Abstract Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target PK/PD exposures associated with therapeutic effect in the neutropenic mouse pneumonia model against 10 MSSA/MRSA strains. The area under the concentration-time curve (AUC)/MIC associated with 1-log kill was noted at 24h ELF and plasma AUC/MIC exposures of ∼2 (ELF range
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Two new flavones, 8,4 ′-dimethoxy-6-(2-oxopropyl)-flavone (1) and 8,4 ′-dimethoxy-6-(3-hydroxypropyl)- flavone (2), were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1 and2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds1 and2 exhibited weak active with diameter of inhibition zone (IZD) 10.8 ± 1.0 and 9.3 ± 0.8 mm, respectively. Compounds1 and2 were also tested for antioxidant activity, and they show good an...
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
ConclusionAccording to this study MDR efflux pumps not only cause high-level resistance but also it considerably associated with over-expression of these genes. Due to the selective pressure on MRSA isolate, the enormous diversity of plasmid-encoded genes had been recorded in different regions, owing to the various numbers and types of isolates in each study or types of disinfectants for general use.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, copper (Cu) and zinc (Zn) as well as phosphorus (P) were co-doped into a Ti–6Al–4V titanium alloy via micro-arc oxidation (MAO). The entrance mechanisms of Cu and Zn into MAO coatings were investigated by an orthogonal experiment. The results show that Cu and Zn in Cu–Zn–P coatings separately exist mainly in the forms of Cu2O and Zn3(PO4)2. The Cu content in MAO coating increases with increasing EDTA-CuNa2 and KOH concentrations and decreasing phytic acid concentration but is nearly independent of EDTA-ZnNa2 concentration. The Zn content increases with increasing EDTA-ZnNa2 concentrat...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
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