Efficacy of the biocide Steri-7 against the common Gram-negative bacterial pathogens (Burkholderia cenocepacia, Burkholderia gladioli, Burkholderia multivorans, Pseudomonas aeruginosa and Stenotrophomonas maltophilia) associated with cystic fibrosis (CF).

Efficacy of the biocide Steri-7 against the common Gram-negative bacterial pathogens (Burkholderia cenocepacia, Burkholderia gladioli, Burkholderia multivorans, Pseudomonas aeruginosa and Stenotrophomonas maltophilia) associated with cystic fibrosis (CF). Br J Biomed Sci. 2013;70(2):80-1 Authors: Moore JE, Rao JR PMID: 23888610 [PubMed - indexed for MEDLINE]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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Abstract Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from cystic fibrosis patients. Treatment with aerosolized levofloxacin for four days produced at least one log CFU of bacterial killing against all strains tested and suggests possible utility in the treatment of lung infections caused by B. cepacia. PMID: 31712215 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Burkholderia cenocepacia is a human opportunistic pathogen causing devastating symptoms in patients suffering from immunodeficiency and cystic fibrosis. Out of the 303 B. cenocepacia strains with available genome...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
Individuals with cystic fibrosis (CF) harbor lifelong respiratory infections that are typically polymicrobial. The most frequently cultured bacteria from CF airways are Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus spp., Stenotrophomonas maltophilia, Achromobacter spp., Burkholderia cepacia complex, and non-Tuberculous Mycobacteria [1]. Recently, a growing body of CF respiratory microbiome literature has identified additional bacterial taxa present in CF respiratory secretions, including many genera containing anaerobic species like Prevotella spp.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Publication date: Available online 25 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Gabriella Costabile, Romina Provenzano, Alberto Azzalin, Viola Camilla Scoffone, Laurent R. Chiarelli, Valeria Rondelli, Isabelle Grillo, Thomas Zinn, Alexander Lepioshkin, Svetlana Savina, Agnese Miro, Fabiana Quaglia, Vadim Makarov, Tom Coenye, Paola Brocca, Giovanna Riccardi, Silvia Buroni, Francesca UngaroAbstractC109 is a potent but poorly soluble FtsZ inhibitor displaying promising activity against Burkholderia cenocepacia, a high-risk pathogen for cystic fibrosis (CF) sufferers. To harness C109 for ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
In vitro Activities of β-Lactam-β-Lactamase Inhibitor Antimicrobial Agents Against Cystic Fibrosis Respiratory Pathogens. Antimicrob Agents Chemother. 2019 Oct 14;: Authors: Caverly LJ, Spilker T, Kalikin LM, Stillwell T, Young C, Huang DB, LiPuma JJ Abstract We tested the in vitro activities of ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam, piperacillin-tazobactam, and 11 other antimicrobial agents against 420 Burkholderia, Achromobacter, Stenotrophomonas, and Pandoraea strains, 89% of which were cultured from respiratory specimens from persons with cystic fibrosis. A...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract Since the discovery of penicillin, microbes have been a source of antibiotics that inhibit the growth of pathogens. However, with the evolution of multi-drug resistant (MDR) strains, it remains unclear if there is an abundant or limited supply of natural products to be discovered that are effective against MDR isolates. To identify strains that are antagonistic to pathogens, we examined a set of 471 globally derived environmental Pseudomonas strains (env-Ps) for activity against a panel of 65 pathogens including Achromobacter spp., Burkholderia spp., Pseudomonas aeruginosa, and Stenotrophomonas spp. isola...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Burkholderia contaminans is one of the 20 closely related bacterial of the Burkholderia cepacia complex, a group of bacteria that are ubiquitous in the environment and capable of infecting people with cystic fibr...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Case report Source Type: research
;o JH Abstract Bacteria of the Burkholderia cepacia complex (Bcc) are ubiquitous multidrug resistant organisms and opportunistic pathogens capable of causing life threatening lung infections among cystic fibrosis (CF) patients. No effective therapies are currently available to eradicate Bcc bacteria from CF patients, as these organisms are inherently resistant to the majority of clinically available antimicrobials. An immunoproteomics approach was used to identify Bcc proteins that stimulate the humoral immune response of the CF host, using bacterial cells grown under conditions mimicking the CF lung environment a...
Source: New Biotechnology - Category: Biotechnology Authors: Tags: N Biotechnol Source Type: research
A 30-year-old cystic fibrosis (CF) male with recurrent multi-drug resistant Burkholderia multivorans infections developed persistent bacteremia, despite high-dose antibiotics for>10 days, and ventilator as well as venovenous (VV) extracorporeal membrane oxygenation (ECMO) dependence limiting his transplant candidacy.1,2 No non-pulmonary sources of infection were identified; his chest radiograph demonstrated significant pulmonary disease. We performed bilateral pneumonectomies to clear his infection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
A 30-year-old male with cystic fibrosis with recurrent multidrug-resistant Burkholderia multivorans infections developed persistent bacteremia, despite high-dose antibiotics for>10 days and ventilator as well as veno-venous (VV) extracorporeal membrane oxygenation (ECMO) dependence limiting his transplant candidacy.1,2 No non-pulmonary sources of infection were identified; his chest radiograph demonstrated significant pulmonary disease. We performed bilateral pneumonectomies to clear his infection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: CASE ANECDOTES Source Type: research
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