[PERSPECTIVES] The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging

This article focuses on new insights gained through the use of heterochronic parabiosis models, in which an old mouse and a young circulatory system are joined. By studying the brains of both young and old mice, researchers are beginning to uncover circulating proneurogenic "youthful" factors and "aging" factors that decrease stem-cell activity and neurogenesis. Ultimately, the identification of factors that influence stem-cell aging may lead to strategies that slow or even reverse age-related decreases in neural-stem-cell (NSC) function and neurogenesis.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Aging PERSPECTIVES Source Type: research