Assessing impact of asthma and eczema on children's lives

(Northwestern University) A new Northwestern Medicine project, 'Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments' (AAD-PEPR), will focus on two common childhood diseases that affect almost 25 percent of American children under age 18.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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ConclusionsScreening programs need to identify nurses who develop chlorhexidine sensitivity due to occupational exposure. Strategies to mitigate risk should provide alternatives for those with sensitization.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
AbstractThis experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA) –induced atopic dermatitis (AD)–like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10 mg/kg, i.p.) was treated once daily from day 9 to day 14 before TMA treatment. Histological analysis was performed and auricular lymph node weights, ear thicknesses, skin water contents,...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Family history of allergy and asthma and early onset of eczema are known risk factors for early life sensitization. Whether these risk factors result in different sensitization patterns is unknown.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
In this study, we tried to reveal the allergenic potential of several Asteraceae species. The Asteraceae-related allergy symptoms involve eczema, hay fever, asthma, or even anaphylaxis. Furthermore, the evidence of severe cross-reactivity with food and pollen allergens (PFS) in patients sensitive to Asteraceae allergens have been announced. Further identification and characterization of secondary metabolites and possible allergens in Asteraceae are necessary for the better understanding of Asteraceae-related immune response. The Asteraceae allergy screening panel (the SL mix and the Compositae mix of five plant species) is...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Regeneron Pharmaceuticals was awarded federal approval Friday to market its Dupixent drug to treat patients with moderate to severe asthma. The drug developer, which makes bulk medications at its East Greenbush, New York, manufacturing complex, already had been marketing the medication for use in patients with eczema or atopic dermatitis. The U.S. Food and Drug Administration approved Dupixent for eczema patients in March 2017. Then, late last week, the FDA gave Regeneron (Nasdaq: REGN) and its…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
CONCLUSIONS: The findings of this review are limited to montelukast. There was a lack of evidence addressing the review question, and the quality of the available evidence for most of the measured outcomes was low. Some primary and secondary outcomes were not addressed at all, including long-term control.We found no evidence of a difference between montelukast (10 mg) and placebo on disease severity, pruritus improvement, and topical corticosteroid use. Very low-quality evidence means we are uncertain of the effect of montelukast (10 mg) compared with conventional treatment on disease severity. Participants in only one stu...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease. Very low-quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA. Further trials are recommended before implementation of this practice.We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed. PMID: 30338526 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
(American College of Allergy, Asthma, and Immunology) A new study suggests that African-Americans may face a greater struggle to find effective therapies for atopic dermatitis than European-Americans. The study used molecular profiling to study the skin of both groups.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Atopic Dermatitis (AD) prevalence and risk factors in the US-population are not fully elucidated. A study from the 2010 National Health Interview Survey (NHIS) found that 10.2% of US adults reported having “dermatitis, eczema, or any other red, inflamed skin rash”1 in the past 12 months, likely overestimating AD prevalence by including other rashes. Further, 3.2% reported having rash with asthma and/or hay fever1, likely underestimating AD prevalence by excluding intrinsic AD or those with remote history of atopic disease.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Atopic dermatitis (AD) prevalence and risk factors in the US population are not fully elucidated. A study from the 2010 National Health Interview Survey (NHIS) found that 10.2% of US adults reported having “dermatitis, eczema, or any other red, inflamed skin rash”1 in the past 12 months, likely overestimating AD prevalence by including other rashes. Furthermore, 3.2% reported having rash with asthma or hay fever,1 likely underestimating AD prevalence by excluding intrinsic AD or those with a remot e history of atopic disease.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
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