What are the Most Common Arboviruses in Children in the US?
Discussion Arboviruses are viruses transmitted by arthropods (primarily mosquitos and ticks) to humans. Most infections are asymptomatic. Many others have mild symptoms such as an influenza-like illnesses. But for some patients they can cause neuroinvasive disease with meningitis, encephalitis and flaccid paralysis. Some patients also unfortunately die. Diagnosis is by serum or cerebrospinal fluid IgM antibody to the specific virus. Treatment is supportive only as there is no specific treatment and currently there are no vaccines for prevention. Mosquito bite and tick bite prevention are the best options for families and can be reviewed here. A systematic review of West Nile Virus (WNV) neuroinvasive disease in adults showed those infected can have a lengthy recovery with many sequelae, particularly muscle weakness, fatigue, myalgia and headache commonly along with memory loss, depression and concentrating difficulty. Common arbovirus characteristics include: West Nile Virus Flavivirus Transmitted by Culex mosquito with birds as reservoir Seen in areas of Africa (originally identified in 1937 in Uganda in the West Nile District), Europe, the Middle East, North America and West Asia Has spread to most states in the United States and many Canadian provinces and is the most common reported arbovirus in children Older children and teenagers seem to be more common Incubation period usually 2-6 days, but 2-14 days is possible 70-80% asymptomatic, 20% influenza like illness (i.e...
Immunotherapy is a promising method of treatment for a number of cancers. Many of the curative results have been seen specifically in advanced-stage melanoma. Despite this, single-agent therapies are only successful in a small percentage of patients, and relapse is very common. As chemotherapy is becoming a thing of the past for treatment of melanoma, the combination of cellular therapies with immunotherapies appears to be on the rise in in-vivo models and in clinical trials. These forms of therapies include tumor-infiltrating lymphocytes, T-cell receptor, or chimeric antigen receptor-modified T cells, cytokines [interleuk...
In the current era of checkpoint inhibitors, some patients with metastatic melanoma have shown a significant improvement in survival. However, optimization of immunotherapy is an ongoing effort. Monocyte-derived dendritic cell (MODC) vaccines have been shown in clinical trials to be safe and capable of inducing tumor-specific immunity as well as occasional objective clinical responses. Here, we conducted a three-arm pilot clinical study in 15 patients with metastatic melanoma to evaluate three types of MODC vaccines, differing only by strategies of tumor antigen delivery. MODCs were isolated from each patient and loaded wi...
ConclusionsBrain uptake of [18F]PSS232 matched the distribution of mGlu5 and followed a two-tissue compartment model. The well-defined kinetics and the possibility to use reference tissue models, obviating the need for arterial blood sampling, make [18F]PSS232 a promising fluorine-18 labeled radioligand for measuring mGlu5 density in humans.
HIGH blood pressure symptoms include chest pain, severe headaches, and difficulty breathing. But, you could lower your risk of hypertension by adding these cheap supplements to your diet, a nutritionist has revealed.
Researchers have identified 17 gene variants, 14 of which are novel, that potentially increase the risk for depression, adding to evidence that depression is at least partially a genetic disorder.Medscape Medical News
In this report, through use of genetically modified mice and pharmacological inhibitors, we demonstrate that the absence or inhibition of ketohexokinase (Khk), an enzyme upstream of aldolase B, is sufficient to prevent hypoglycemia and liver and intestinal injury associated with HFI. Herein we provide evidence for the first time to our knowledge of a potential therapeutic approach for HFI. Mechanistically, our studies suggest that it is the inhibition of the Khk C isoform, not the A isoform, that protects animals from HFI.
[This Day] Abuja -The United Nations International Children's Fund (UNICEF) has said that despite tremendous progress made in the reduction of child mortality rate in Nigeria, about 4.3 million children still miss out on vaccinations every year.
[This Day] As Nigerians join the rest of the world to mark the World Malaria Day April 25, 2018, with the theme: 'End Malaria for Good,' a Nigerian firm, Superior Pharmaceuticals, makers of Sumether and Sumether Plus a combination of Artemether and Lumefantrine popularly known as ACT combination therapy, will be actively involved in the campaign by giving out free malaria drugs.
[Daily Trust] The United Nations Children's Fund (UNICEF) said 4.3 million children in Nigeria still miss out of routine vaccinations.
[Daily Trust] The coverage of the main vaccines offered through routine immunization has declined as 4.3 million children in Nigeria still miss vaccinations every year, the United Nations Children's Fund (UNICEF), has said.
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