Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination

Conclusions Intraperitoneal TAMs in gastric cancer patients with peritoneal dissemination were polarized to the M2 phenotype, and could contribute to tumor proliferation and progression. Therefore, intraperitoneal TAMs are expected to be a promising target in the treatment of peritoneal dissemination in gastric cancer.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

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We report 2 elderly female patients with LPE who developed squamous cell carcinoma (SCC). Both underwent laparoscopic ischemic gastric preconditioning followed 2 weeks later by 3-field esophagectomy. Final pathological stages were carcinoma-in-situ and pT3N2, respectively. No adjuvant therapy was given. The patient with in-situ cancer has no evidence of recurrence at 24 months. The 2nd patient opted to follow up locally and died 8 months later. LPE should be closely monitored for malignant degeneration. Esophagectomy should be considered when malignancy is detected.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conditions:   Gastric Cancer;   Atrophic Gastritis;   Gastric Dysplasia;   H.Pylori Infection Interventions:   Device: Breath sampling for VOC detection;   Procedure: Surgery material collection for VOC headspace analysis;   Diagnostic Test: Upper endoscopy;   Diagnostic Test: Microbiota testing Sponsors:   University of Latvia;   Technion, Israel Institute of Technology;   University of Ulm;   UPPSALA UNIVERSITET;   JLM Innovation ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: A simple, convenient, accurate, and robust 2-dimensional liquid chromatography method was developed and verified, which successfully determined the plasma concentrations of apatinib in patients with gastric cancer.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Cancer Gene Therapy, Published online: 16 July 2019; doi:10.1038/s41417-019-0125-7Discovery and validation of methylated-differentially expressed genes in Helicobacter pylori-induced gastric cancer
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsBoth LI and VI were significant predictors of LN metastasis. The risk of LN metastasis was augmented when both LI and VI were positive. Therefore, LI and VI should be evaluated separately in patients with non-curative endoscopic resection. Additive surgery should be recommended for patients with LI and/or VI.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
In conclusion, TTB inhibited OGD/R-induced astrocytes oxidative stress, at least partially through inhibition of HIF1α and VEGF via Nrf2/HO-1 signaling pathway.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This article summarizes the milestones in the development of camrelizumab leading to this first approval for classical Hodgkin lymphoma.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionsThis case highlights the importance of genetic testing with rare malignancies because the full scope of phenotypic sequelae for known hereditary syndromes has not been mapped.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Condition:   Gastric Cancer Intervention:   Sponsors:   Fundación para la Investigación del Hospital Clínico de Valencia;   Instituto Nacional de Cancerologia de Mexico;   VU University Medical Center;   Pontificia Universidad Catolica de Chile;   Vall d'Hebron Institute of Oncology;   INSTITUTO ALEXANDER FLEMING;   Hospita l Central del IPS;   INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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