Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity.

Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity. Curr Opin Immunol. 2015 Nov 19;38:30-38 Authors: Naquet P, Giessner C, Galland F Abstract Recent developments have demonstrated that metabolic rewiring imposed by adaptation of tissues to stress leads to the release of various metabolites which directly or indirectly impact innate immune responses and inflammation. Some metabolites can behave as second messengers and leave local cues in tissues. Immune cells which infiltrate stressed tissues reorient their metabolism to cope with these microenvironmental cues while preserving their effector functions in tissues. PMID: 26605965 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research