The immune injury effects and clinical significance of eosinophils in auto-immune-related hematocytopenia.

The immune injury effects and clinical significance of eosinophils in auto-immune-related hematocytopenia. J Immunoassay Immunochem. 2015;36(2):128-41 Authors: Sun LF, Han B, Wu QQ, Wang GC, Hao HF, Du YH, Zhang Y Abstract Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN- γ were increased but there was no significance on IL-2 level. In marrow of AIRH, activated EOS expressed POX, and other molecules, it played various cell-mediated immunity injury roles to hemocyte. EOS might be possessed with multiple immunological fuctions, it playes an important immune effect in AIRH autoimmune pathological processes. PMID: 24749926 [PubMed - indexed for MEDLINE]
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research