Duration of blood plasma cortisol suppression after a low-dose dexamethasone suppression test in dogs

Abstract The aim of this study was to determine the duration of the suppressive effect on the hypothalamus–pituitary–adrenocortical axis as measured by plasma cortisol concentration after injection of a low dosage of dexamethasone (0.01 mg/kg BW) used within the low-dose dexamethasone suppression test (LDDST). A LDDST was performed on ten clinically healthy dogs with unremarkable haematological and plasma biochemical profiles, abdominal X-ray, abdominal ultrasonography and fine needle aspiration cytology of the liver. Two of them were excluded from the analysis. Blood samples were collected at baseline, 4 and 8 h (standard protocol of a LDDST) and, additionally, at 24, 48, 72 and 96 h after the application of dexamethasone. Plasma cortisol concentrations 10 ng/ml. The median 4, 8 and 24 h plasma cortisol concentrations were significantly lower than the median baseline plasma cortisol concentration, whereas at the remaining times no significant changes were seen compared to the median baseline value. The suppression of plasma cortisol induced by dexamethasone in a dosage of 0.01 mg/kg BW can last at least 48 h in individual dogs. Therefore, a repeated LDDST should be performed at the earliest 3 days after the prior test to prevent artificial results.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Both incidence and mortality of cholangiocarcinoma (CCA) are increasing worldwide. The presence of malignant regional lymph node (MRLN) involvement precludes curative surgical resection or liver transplantation. Thus it is critical to determine the status of indeterminate regional lymph nodes (IRLN) during staging. Cross sectional imaging lacks sufficient sensitivity for IRLN identification and poorly discriminates benign from MRLN when IRLN are identified. While limited data have supported the utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for detection of MRLN in perihilar CCA (pCCA), there is n...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Rationale: Cancer recurrence and metastasis after liver transplantation (LT) is common in some hepatocellular carcinoma (HCC) patients. The most common sites of extrahepatic metastases are lung, regional lymph node, adrenal gland, and bone. To our knowledge, HCC metastasis to the seminal vesicle after LT has not been reported in the literature. Patient concerns: A 56-year-old Asian man presented at hospital with a 9-year history of orthotopic LT because of HCC. The patient underwent surgery and radiotherapy for HCC metastasis to adrenal gland and 1 year later, chemotherapy for peritoneal metastasis. A few months later...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 23 August 2018Source: Journal of Visceral SurgeryAuthor(s): B. Aussilhou, S. Dokmak, F. Dondero, D. Joly, F. Durand, O. Soubrane, J. BelghitiSummaryPolycystic liver disease (PLD) may consist of autosomal dominant PLD or isolated PLD without renal impairment. The natural history of liver cysts is to increase in size and number, causing progressive disease that can lead to very large and incapacitating hepatomegaly. Only symptomatic hepatomegaly (pain, inability to eat, weight loss, dyspnea) or cystic complications such as infection or intracystic hemorrhage should be treated. The treatment...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
We present the case of a 64-year-old male with known history of MM admitted with acute respiratory failure and a chest wall mass. Chest CT revealed patchy interstitial and alveolar opacities with no pulmonary masses or nodules. Bronchoalveolar lavage (BAL) was performed, with flow cytometry demonstrating monoclonal plasma cells expressing CD38, CD138 and CD56 with lambda light chain restriction. Fine Needle Aspiration of chest wall mass revealed CD138-positive cells as well.Review of the literature revealed only one other documented case of a patient presenting with both interstitial lung parenchymal involvement with MM as...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
CONCLUSIONS An increased ratio of CD8+CD158a+ cells, measured by flow cytometry, between graft blood and PB was associated with improved renal function. PMID: 28115732 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
ConclusionIn patients with HCC and lymphadenopathy, EUS-guided FNA detected metastatic disease and precluded liver transplantation in approximately one third of patients.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Authors: Rossi G, Lafont E, Gasperini L, Dokmak S, Ronot M, Rossi B, Zarrouk V, Fantin B, Lefort A Abstract Liver abscess is a rare and severe infection. Incidence increases because of aging of population, advances in liver and biliary surgery including liver transplantation, and immunodeficiency factors. Diagnosis depends mainly on imaging and needle aspiration for microbiological identification. Treatment is based on antibiotics, percutaneous or surgical drainage, and control of the primary source. PMID: 27639909 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Conclusion: EUS guided FNA is safe in patients with cirrhosis and modified the management in 14/46 (30.4 %) patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
We reported a liver transplant recipient with Nocardia thyroiditis and pneumonia after receiving high dose immunosuppressants to preserve his graft. The patient is a 50-year-old male who developed hepatitis C virus-related liver cirrhosis and received a liver transplant. Seven months post-transplantation the patient developed graft rejection, which was treated with 3 days pulse dose methyl-prednisolone followed by an increased dose of his tracolimus, mycophenolate and prednisolone. He presented to the hospital with a 2 week history of fever, tenderness in his anterior neck and dry cough. On admission his temperature was 39...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
CONCLUSION: Hepatic angiosarcoma is a malignant vascular neoplasia, the potential curative option is surgery with tumour free margins. Liver transplantation remains controversial because of its poor prognosis in the short term. PMID: 26144270 [PubMed - as supplied by publisher]
Source: Cirugia y Cirujanos - Category: Surgery Authors: Tags: Cir Cir Source Type: research
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