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Methodological quality of guidelines for management of Lyme neuroborreliosis

Background: Many aspects of clinical management of Lyme neuroborreliosis are subject to intense debates. Guidelines show considerable variability in their recommendations, leading to divergent treatment regimes. The most pronounced differences in recommendations exist between guidelines from scientific societies and from patient advocacy groups. Assessment of the methodological quality of these contradictory guideline recommendations can be helpful for healthcare professionals. Methods: Systematic searches were conducted in MEDLINE and databases of four international and national guideline organizations for guidelines on Lyme neuroborreliosis published from 1999–2014. Characteristics (e.g., year of publication, sponsoring organization) and key recommendations were extracted from each guideline. Two independent reviewers assessed the methodological quality of each guideline according to the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. AGREE II scores from guidelines developed by scientific societies and from patient advocacy groups were compared across domains. Results: We identified eight eligible guidelines of which n = 6 were developed by scientific societies and n = 2 by patient advocacy groups. Agreement on AGREE II scores was good (Cohen’s weighted kappa = 0.87, 95 % CI 0.83–0.92). Three guidelines, all from scientific societies, had an overall quality score of ≥ ...
Source: BMC Neurology - Category: Neurology Authors: Source Type: research

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This article is protected by copyright. All rights reserved. Borrelia burgdorferi, Lyme disease agent, harbors no enzymes to synthesize or degrade polyamines yet does contain the genes encoding a putative polyamine uptake system (potABCD). Here, we demonstrated that the PotABCD is a spermidine‐specific transporter system that is essential for survival. The genes are upregulated during tick feeding concomitantly with the decrease of osmoliarity which has been shown to trigger virulence factor expression. The potABCD genes are regulated in a RpoN‐dependent, RpoS‐independent, BosR‐independent fashion.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research
Publication date: 3 April 2018 Source:Neuroscience Letters, Volume 671 Author(s): Geetha Parthasarathy, Mario T. Philipp Lyme neuroborreliosis, caused by the gram-negative bacterium Borrelia burgdorferi, may affect the central and/or peripheral nervous systems. In previous studies, we showed that human oligodendrocytes exposed to the bacteria undergo apoptosis in an inflammatory environment, and that inflammatory pathways trigger cell-death pathways. We further demonstrated that several receptor tyrosine kinases were involved in triggering downstream effects, leading to inflammation and apoptosis. Toll-like receptors TLR2...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Cerebrospinal fluid CXCL13 is a marker for Lyme neuroborreliosis (LNB). CXCL13 lateral flow immunoassay (LFA) was compared to CXCL13 ELISA. CXCL13 LFA results correlated strongly with CXCL13 ELISA results. CXCL13 LFA is a rapid and easy to perform test, which is suitable for routine point-of-care diagnostics of suspected LNB patients.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Tags: Note Source Type: research
Borrelia burgdorferi infection is common in horses living in Lyme endemic areas and the geographic range for exposure is increasing. Morbidity after B. burgdorferi infection in horses is unknown. Documented, naturally occurring syndromes attributed to B. burgdorferi infection in horses include neuroborreliosis, uveitis, and cutaneous pseudolymphoma. Although other clinical signs such as lameness and stiffness are reported in horses, these are often not well documented. Diagnosis of Lyme disease is based on exposure to B. burgdorferi, cytology or histopathology of infected fluid or tissue and antigen detection. Treatment of...
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: ACVIM Consensus Statement Source Type: research
Conclusion: NFS is a unique tool that can be used universally to assess the condition of patients with LD.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusions and Clinical ImportancePositive Lyme multiplex results were common in horses with neurologic diseases and did not adequately differentiate horses with neuroborreliosis from horses with other disorders.
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: STANDARD ARTICLE Source Type: research
Authors: Boyer PH, Kieffer P, de Martino SJ, Zilliox L, Vogel JY, Jaulhac B, Hansmann Y PMID: 29449048 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
It was an exercise session in a local park that almost became the mother-of-two Nell McAndrew's undoing – after a tiny tick bite led to her developing potentially life-changing Lyme disease.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(Natural News) A study, published in the journal Frontiers in Medicine, found that more than 50 percent of Lyme disease survivors still suffer from severe, persistent symptoms even after being clinically cleared of the infection. A team of researchers from John Hopkins University School of Medicine evaluated 61 individuals who were either self- or physician-referred...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
In this study using 3956 control sera, we demonstrated that although this 2-tier testing algorithm does significantly improve diagnostic specificity compared with each of the EIAs individually, the WCS EIA and the C6 peptide EIA are not independent tests.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research
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