Methodological quality of guidelines for management of Lyme neuroborreliosis

Background: Many aspects of clinical management of Lyme neuroborreliosis are subject to intense debates. Guidelines show considerable variability in their recommendations, leading to divergent treatment regimes. The most pronounced differences in recommendations exist between guidelines from scientific societies and from patient advocacy groups. Assessment of the methodological quality of these contradictory guideline recommendations can be helpful for healthcare professionals. Methods: Systematic searches were conducted in MEDLINE and databases of four international and national guideline organizations for guidelines on Lyme neuroborreliosis published from 1999–2014. Characteristics (e.g., year of publication, sponsoring organization) and key recommendations were extracted from each guideline. Two independent reviewers assessed the methodological quality of each guideline according to the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. AGREE II scores from guidelines developed by scientific societies and from patient advocacy groups were compared across domains. Results: We identified eight eligible guidelines of which n = 6 were developed by scientific societies and n = 2 by patient advocacy groups. Agreement on AGREE II scores was good (Cohen’s weighted kappa = 0.87, 95 % CI 0.83–0.92). Three guidelines, all from scientific societies, had an overall quality score of ≥ ...
Source: BMC Neurology - Category: Neurology Authors: Source Type: research

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Conclusions/SignificanceThese preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We report on five cases of patients with a diagnosis of neuroborreliosis based on clinical symptoms, serologic tests and MR imaging results. However, neither of them fulfils the diagnostic criteria for definite neuroborreliosis. Are the diagnostic criteria still valid or is there a need to revis e them? Is our diagnosis correct? Are these cases post-Lyme auto-immune neuronal inflammation, and not due to still active spirochetal infection? Do we need to consider immunosuppressive therapy instead of third-generation cephalosporins?
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Publication date: Available online 14 December 2018Source: Ticks and Tick-borne DiseasesAuthor(s): George Psevdos, Teresa Khoo, Robert Chow, Christopher L Romano, Scott CampbellAbstractIn North America, Lyme disease (LD) is caused predominantly by the spirochete Borrelia burgdorferisensu stricto, and is transmitted by blacklegged ticks. Long Island, New York, is highly endemic for the disease. The C6 peptide (C6P) is currently used as a screening test for LD in our institution. Our objective was to examine how screening with C6P concorded with diagnosis of LD at the Veterans Affairs Medical Center, Northport, Long Island. ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Authors: Eldin C, Raffetin A, Bouiller K, Hansmann Y, Roblot F, Raoult D, Parola P Abstract Lyme disease is a tick-borne bacterial disease with polymorphic clinical manifestations (cutaneous, rheumatological, and neurological). In recent years the issue of the diagnosis of this infection has been highly publicized on the Internet and other media in Europe and America. Some patients and physicians may share the perception that the diagnosis of the infection is not reliable in France. We reviewed current European and American guidelines on Lyme disease and performed a methodological evaluation of all guidelines. We r...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Scientists at the University of Cincinnati say the hungrier ticks are, the harder they try to find people or other hosts -- a finding that could have implications for the spread of tick-borne diseases such as Lyme or Rocky Mountain Spotted Fever. The researchers explain that starved ticks' ...This is an NSF Multimedia Gallery item.
Source: NSF Multimedia Gallery - Category: Science Source Type: video
Scientists at the University of Cincinnati say the hungrier ticks are, the harder they try to find people or other hosts -- a finding that could have implications for the spread of tick-borne diseases such as Lyme or Rocky Mountain Spotted Fever. The researchers explain that starved ticks' metabolisms speed up, causing them to hunt more aggressively.
Source: The Discovery Files - Category: Science Authors: Source Type: podcasts
(Natural News) Lyme disease can be difficult to treat. If caught early, a round of antibiotics can clear up the infection and resolve symptoms, but that isn’t always the case. Roughly 10 to 20 percent of sufferers go on to experience ongoing symptoms like joint pain and fatigue. Known as persistent Lyme infection, it can...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Scientists at the University of Cincinnati say the hungrier ticks are, the harder they try to find people or other hosts -- a finding that could have implications for the spread of tick-borne diseases such as Lyme or Rocky Mountain Spotted Fever. The researchers explain that starved ticks' metabolisms speed up, causing them to hunt more aggressively.
Source: The Discovery Files - Category: Science Authors: Source Type: podcasts
Vitomir Djokic, Shekerah Primus, Lavoisier Akoolo, Monideep Chakraborti, Nikhat Parveen
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 6 December 2018Source: Ticks and Tick-borne DiseasesAuthor(s): Tereza Rojko, Petra Bogovič, Stanka Lotrič-Furlan, Katarina Ogrinc, Tjaša Cerar-Kišek, Urška Glinšek Biškup, Miroslav Petrovec, Eva Ružić-Sabljić, Andrej Kastrin, Franc StrleAbstractThe aims of the study were to determine the frequency of borrelial infection in patients with peripheral facial palsy (PFP) and to compare clinical and laboratory characteristics of patients with borrelial PFP and patients with PFP of unknown etiology.Adult patients with PFP who presented at our department be...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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