Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.
Mem Inst Oswaldo Cruz. 2015 Nov 24;
Authors: Souza NB, Aguiar AC, Oliveira AC, Top S, Pigeon P, Jaouen G, Goulart MO, Krettli AU
Abstract
This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.
PMID: 26602875 [PubMed - as supplied by publisher]

Source: Memorias do Instituto Oswaldo Cruz - November 24, 2015 Category: Infectious Diseases Authors: Souza NB, Aguiar AC, Oliveira AC, Top S, Pigeon P, Jaouen G, Goulart MO, Krettli AU Tags: Mem Inst Oswaldo Cruz Source Type: research