Fibrinogen and Alpha 1-Antitrypsin in COPD ExacerbationsFibrinogen and Alpha 1-Antitrypsin in COPD Exacerbations

How are fibrinogen and Alpha 1-antitrypsin associated with exacerbations in COPD? Thorax
Source: Medscape Pathology Headlines - Category: Pathology Tags: Pulmonary Medicine Journal Article Source Type: news

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Conclusion: Quantitative SPECT/CT is useful in pre-surgical evaluation or radiation treatment planning of patients with pulmonary nodule or lung mass. Larger sample size of patients with underlying emphysema is needed to further evaluate the utility of this technique. We recommend Quantitative perfusion SPECT/CT for lobar assessment than traditional regional quantitative perfusion prior to surgery.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Infection/Pulmonary/Outcomes (Poster Session) Source Type: research
PMID: 32417149 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
This study focussed on the neutrophil plasma membrane and, by use of label-free tandem mass spectrometry, the proteome of the neutrophil membrane was compared in forced expiratory volume in 1 s (FEV1)-matched AATD, non-AATD COPD and in AATD patients receiving weekly AAT augmentation therapy (n=6 patients per cohort). Altered protein expression in AATD was confirmed by Western blot, ELISA and fluorescence resonance energy transfer analysis. The neutrophil membrane proteome in AATD differed significantly from that of COPD as demonstrated by increased abundance and activity of primary granule proteins including neutrophil ela...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Lung biology and experimental studies Original Articles: COPD and basic science Source Type: research
Authors: Gaeckle NT, Stephenson L, Reilkoff RA Abstract Alpha-1 Antitrypsin Deficiency (A1AD) is a hereditary condition characterized by low levels of circulating alpha-antitrypsin (AAT) in plasma. It is the best understood genetic risk factor for the development of chronic obstructive pulmonary disease (COPD). The diagnosis of A1AD is under-recognized. While there is a significant heterogeneity in disease presentation in relation to the severity of symptoms and prognosis, it is not uncommon for young individuals, including pregnant women to already have moderate to advanced lung disease at the time of diagnosis. R...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
CONCLUSION: Our results suggested that changes in the desialylated human serum N-glycome holds glycoprotein specific molecular diagnostic potential for malignant and inflammatory lung diseases, which can be modeled with the five-protein mixture. PMID: 32321401 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research
The gene encoding alpha-1 antitrypsin (SERPINA1) is the strongest genetic risk locus for Chronic obstructive pulmonary disease (COPD) susceptibility. While the deficiency alleles PI types S and Z increase the risk for COPD in ZZ homozygotes and ZS compound heterozygotes as compared with wild-type allele homozygotes (MM), contradictory data exists regarding MZ heterozygotes. Ortega et al (Am J Respir Crit Care Med. 2019 Oct 29. https://doi.org/10.1164/rccm.201904-0769OC) performed deep next-generation sequencing and a comprehensive genetic study of this locus in a large cohort of current and former heavy smokers complemente...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: News beyond our pages Source Type: research
α1-antitrypsin deficiency (AATD) is a hereditary disorder associated with a risk of developing liver disease and pulmonary emphysema, and other chronic respiratory disorders (mainly asthma and bronchiectasis); Z variant is the commonest deficient variant of AAT. Determining AAT concentration in serum or plasma and identifying allelic variants by phenotyping or genotyping are fundamental in the diagnosis of AATD. Initial evaluation and annual follow-up measurement of lung function, including post-bronchodilator forced expiratory volume in 1 s and gas transfer inform on disease progression. Lung densitometry is th...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Genetics Review Source Type: research
AT.AR Abstract INTRODUCTION: Alpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVE: To estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODS: This was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
Conclusions: AATD patients with BC seem to have a higher exacerbations burden, a poorer pulmonary function at diagnosis, a greater FEV1 decline and lower survival than non-BC patients, although no statistical significance was achieved in any of the performed analyses.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Patients with inherited α1-antitrypsin (AAT) deficiency (ZZ-AATD) and severe chronic obstructive pulmonary disease (COPD) frequently experience exacerbations. We postulated that inhalation of nebulised AAT would be an effective treatment. We randomly assigned 168 patients to receive twice-daily inhalations of 80 mg AAT solution or placebo for 50 weeks. Patients used an electronic diary to capture exacerbations. The primary endpoint was time from randomisation to the first event-based exacerbation. Secondary endpoints included change in the nature of the exacerbation as defined by the Anthonisen criteria. Sa...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
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